Bacteria and Archaea: A new era of cancer therapy.

Autor: Moghimipour E; Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Abedishirehjin S; Young Researchers and Elite Club, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Baghbadorani MA; Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Handali S; Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran. Electronic address: handali_s81@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2021 Oct 10; Vol. 338, pp. 1-7. Date of Electronic Publication: 2021 Aug 12.
DOI: 10.1016/j.jconrel.2021.08.019
Abstrakt: Cancer is one of the most important mortality in the world. The major drawbacks of chemotherapy are the poor absorption of drugs into tumor tissues and development of resistance against anti-cancer agents. To overcome these limitations, the use of microorganisms has been extensively considered in the treatment of cancer. Microorganisms (bacteria/Archaea) secrete different bioactive compounds that can efficiently inhibit cancer cells growth. Biological nanocarriers derived from microorganisms including outer membrane vesicles (OMVs), bacterial ghosts (BGs) and archaeosomes have also been considered as drug delivery systems. Conjugation of drug loaded nanocarriers to bacteria strongly kills the cancer cells after internalization through the bacteria. Merging of microbiology and nanotechnology may provide versatile microbial nano-hybrids for promising treatment of cancer. This strategy causes more amount of drug to enter into cancer cells. In this review, we present evidence that microorganism, their derivatives as well as their intervention with nanotechnology can be a powerful vehicle for eradication cancer.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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