Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.

Autor: van der Laan CM; Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. C.M.vander.Laan@vu.nl.; The Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands. C.M.vander.Laan@vu.nl., Morosoli-García JJ; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., van de Weijer SGA; The Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands., Colodro-Conde L; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Lupton MK; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Mitchell BL; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., McAloney K; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Parker R; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Burns JM; Faculty of Health Sciences, The University of Sydney, Sydney, Australia., Hickie IB; Brain and Mind Centre, University of Sydney, Camperdown, Australia., Pool R; Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands., Hottenga JJ; Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Nivard MG; Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands., Boomsma DI; Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Behavior genetics [Behav Genet] 2021 Sep; Vol. 51 (5), pp. 592-606. Date of Electronic Publication: 2021 Aug 14.
DOI: 10.1007/s10519-021-10076-6
Abstrakt: We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
(© 2021. The Author(s).)
Databáze: MEDLINE
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