Reference values for the triglyceride to high-density lipoprotein ratio and its association with cardiometabolic diseases in a mixed adult population: The ELSA-Brasil study.

Autor: Lelis DF; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil., Calzavara JVS; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil., Santos RD; Lipid Clinic Heart Institute (Incor) University of São Paulo Medical School Hospital, São Paulo, Brazil., Sposito AC; Cardiology Division, Faculty of Medical Sciences, State University of Campinas (Unicamp), Campinas, SP, Brazil., Griep RH; Laboratory of Health and Environment Education, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil., Barreto SM; Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Molina MDCB; Post Graduate Programme in Public Health, Federal University of Espírito Santo, Vitória, ES, Brazil., Schmidt MI; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Duncan BB; School of Medicine and Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Bensenor I; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil., Lotufo PA; Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, SP, Brazil., Mill JG; Department of Physiological Sciences, Federal University of Espírito Santo, Vitória, ES, Brazil., Baldo MP; Department of Pathophysiology, Montes Claros State University (UNIMONTES), Montes Claros, MG, Brazil. Electronic address: marcelobaldo@ymail.com.
Jazyk: angličtina
Zdroj: Journal of clinical lipidology [J Clin Lipidol] 2021 Sep-Oct; Vol. 15 (5), pp. 699-711. Date of Electronic Publication: 2021 Jul 29.
DOI: 10.1016/j.jacl.2021.07.005
Abstrakt: Background: Among several lipid ratios available, the triglyceride/HDL-cholesterol (TG/HDL-C) may detect individuals at risk of cardiometabolic diseases. However, its reference values for different ethnicities are not well established.
Objective: To define sex- and ethnicity-specific reference values for TG/HDL-C ratio in a large sample of healthy multiethnic adults and test its association with cardiometabolic conditions.
Methods: An apparently healthy sample (n = 2,472), aged 35-74, free of major cardiovascular risk factors, was used to generate the reference values for the TG/HDL-C. Exclusion criteria were diabetes, elevated blood pressure, obesity, hypercholesterolemia, severe hypertriglyceridemia, and smoking history. Cut-offs based on the reference values were tested in the whole ELSA Brasil study (n = 13,245), stratified by sex and ethnicity, to identify cardiometabolic conditions.
Results: TG/HDL-C ratio was higher in men than women, and did not change significantly with age, regardless of sex and ethnicity. Also, black individuals showed lower levels of TG/HDL-C as compared to other ethnic groups. ROC curve showed that the cut-off based on the 75th percentile displayed better sensitivities and specificities for men and women, regardless of ethnicity. Also, the sex- and ethnicity-specific cut-offs based on the 75th percentile were significantly associated with all tested cardiometabolic conditions (hypertension, diabetes, obesity, metabolic syndrome, and insulin resistance). Also, we observed that the use of a single sex-specific cut-off (men: 2.6; women: 1.7) could be used for the different ethnicities with good reliability.
Conclusion: The defined TG/HDL-C cut-offs (men: 2.6; women: 1.7) are reliable and showed good clinical applicability to detect cardiometabolic conditions in a multiethnic population.
Competing Interests: Conflict of Interest RDS has received honoraria related to consulting, speaker activities, or research from Abbott, Ache, Amgen, Astra Zeneca, Esperion, EMS, Getz pharma, Kowa, Libbs, Novo-Nordisk, Novartis, Merck, MSD, Pfizer, PTC Therapeutics, and Sanofi outside the present work. All other authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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