Serosurvey of anti-treponema pallidum (syphilis), anti-hepatitis C virus and anti-HIV antibodies in homeless persons of São Paulo city, southeastern Brazil.

Autor:	Felipetto LG; Federal University of Paraná, Department of Veterinary Medicine, College of Veterinary Science, Curitiba, PR, Brazil., Teider-Junior PI; Federal University of Paraná, Department of Veterinary Medicine, College of Veterinary Science, Curitiba, PR, Brazil., da Silva FFV; Federal University of Paraná, Clinics Hospital, Clinical Analysis Laboratory Unit, Curitiba, PR, Brazil., Couto ACD; Federal University of Paraná, Department of Cellular and Molecular Biology, College of Cellular and Molecular Biology, Curitiba, PR, Brazil., Kmetiuk LB; Federal University of Paraná, Department of Cellular and Molecular Biology, College of Cellular and Molecular Biology, Curitiba, PR, Brazil., Martins CM; State University of Ponta Grossa, Department of Nursing and Public Health, Ponta Grossa, PR, Brazil., Ullmann LS; São Paulo State University, Institute of Biotechnology, Botucatu, São Paulo, Brazil., Timenetsky J; University of São Paulo, Department of Medical Microbiology, São Paulo, Brazil., Santos APD; Purdue University, Department of Comparative Pathobiology, West Lafayette, IN, USA., Biondo AW; Federal University of Paraná, Department of Veterinary Medicine, College of Veterinary Science, Curitiba, PR, Brazil; Federal University of Paraná, Department of Cellular and Molecular Biology, College of Cellular and Molecular Biology, Curitiba, PR, Brazil; Federal University of Paraná, Department of Veterinary Medicine, Curitiba, PR, Brazil. Electronic address: abiondo@ufpr.br.
Jazyk:	angličtina
Zdroj:	The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2021 Jul-Aug; Vol. 25 (4), pp. 101602. Date of Electronic Publication: 2021 Aug 10.
DOI:	10.1016/j.bjid.2021.101602
Abstrakt:	Homeless persons have been considered as one of the most susceptible populations to sexually transmitted infections. In Brazil, these population experienced an increase of 140% from 2012 to 2020. Accordingly, the present study aimed to assess the seroprevalence of anti-Treponema pallidum, anti-HCV, anti-HIV antibodies, and the risk factors associated with homeless persons in a daytime attendance shelter of São Paulo city during the syphilis epidemic in Brazil. Blood samples of 116 volunteers and epidemiological data were conveniently collected in the shelter from June through August 2018. Detection of syphilis, HCV, and HIV antibodies was performed by chemiluminescent microparticle immunoassay (CMIA). CMIA-reagent samples for anti-T. pallidum antibodies were confirmed by Venereal Disease Research Laboratory (VDRL) non-treponemal test. VDRL non-reagent samples were confirmed by treponemal rapid immunochromatographic test. A rapid immunoblot assay confirmed seropositivity to HIV. Overall, anti-T. pallidum antibodies were observed in 29/116 (25.0%), anti-HCV antibodies in 4/116 (3.4%), and anti-HIV antibodies in 2/116 (1.7%) individuals, both co-infected with anti-T. pallidum antibodies. Associated risk factors for syphilis in homeless persons were being born or previously living in another city (p = 0.043) and becoming homeless due to family conflicts (p = 0.035). Besides homeless vulnerability, worldwide shortage of benzathine penicillin supply and increasing of syphilis testing access through rapid testing in primary health care services may have also impacted disease spreading at the time. The prevalence of syphilis found herein is the highest worldwide to date in this population. Competing Interests: Conflicts of interest The authors declare that they have no conflict of interest. (Copyright © 2021 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz: