| Autor: |
Akinwande KS; Department of Chemical Pathology and Immunology, 557715Federal Medical Centre, Abeokuta, Nigeria., Olateru-Olagbegi O; Department of Haematology and Blood Transfusion, 107962University College Hospital, Ibadan, Nigeria., Okwor CJ; Department of Chemical Pathology, 291413University of Nigeria Teaching Hospital, Enugu, Nigeria., Uche CZ; Department of Medical Biochemistry & Molecular Biology, College of Medicine, 107769University of Nigeria, Nigeria., Eni BB; Department of Internal Medicine, 107769University College Hospital, Ibadan, Nigeria., Edem VF; Department of Immunology, University of Ibadan, Ibadan, Nigeria. |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology and industrial health [Toxicol Ind Health] 2021 Sep; Vol. 37 (9), pp. 528-534. Date of Electronic Publication: 2021 Aug 13. |
| DOI: |
10.1177/07482337211030425 |
| Abstrakt: |
Automobile technicians in resource-poor settings often work in poor environments and are exposed to chemicals that put them at risk of ill health and disease. These chemical exposures could affect blood coagulation, leading to bleeding disorders or thrombosis. The present study is aimed at assessing prothrombin test (PT) and activated partial thromboplastin test (aPTT) values, serum zinc (Zn) and copper (Cu) concentrations, and blood lead level (BLL) among occupationally exposed automobile technicians compared to unexposed controls. A total of 140 consenting participants comprising 70 automobile technicians and 70 unexposed controls were recruited for this case-control study. A 6-mL blood sample was drawn from each participant for estimation of BLL, serum Zn and Cu concentrations, and PT and aPTT values. Blood lead level, and serum Zn and Cu concentrations were determined using atomic absorption spectrophotometry, while PT and aPTT values were determined using Innovin PT and Actin FS Activated PTT reagents on the Sysmex CA-101 coagulation analyser. Data were analysed using t-tests, chi-square tests, and logistic and multiple linear regression analyses with statistical significance set at p < 0.05. The mean BLL, serum Zn concentration, and PT and aPTT values were significantly higher in automobile technicians compared to controls. Binary logistic regression showed that automobile technicians had higher odds of elevated PT value (OR = 21.769; p = 0.000), aPTT value (OR = 1.348; p = 0.018), BLL (OR = 1.261; p = 0.000) and serum Zn concentration (OR = 1.063; p = 0.005) than unexposed controls. Linear regression showed significant positive association of PT value with BLL and with serum Zn concentration. Higher PT and aPTT values reflect prolonged blood coagulation time among automobile technicians, which indicates impairment of extrinsic and intrinsic coagulation pathways associated with work-related exposures. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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