A meta-analysis for association of eNOS VNTR 4b/a,  - 786 T > C and + 894G > T polymorphisms with risk of recurrent pregnancy loss.

Autor: Golestanpour H; Department of Genetics, Marvdasht Branch, Azad University, Marvdasht, Iran.; Biotechnology Research Center, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Bahrami R; Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Dastgheib SA; Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. dastgheibsa@gmail.com., Tabatabaei RS; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Javaheri A; Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Karimi-Zarchi M; Department of Obstetrics and Gynecology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.; Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran., Mirjalili SR; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran., Neamatzadeh H; Mother and Newborn Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Jazyk: angličtina
Zdroj: Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2021 Nov; Vol. 304 (5), pp. 1135-1151. Date of Electronic Publication: 2021 Aug 13.
DOI: 10.1007/s00404-021-06172-x
Abstrakt: Background: The association of polymorphisms at nitric oxide synthases (eNOS) gene with recurrent pregnancy loss (RPL) susceptibility has been the focus of attention in several studies. However, the conclusions have been divergent and controversial. Therefore, we performed this study to precisely evaluate the association of eNOS polymorphisms with the risk of RPL.
Methods: A universal search in PubMed, Web of Knowledge, SciELO, MedRxiv, Scopus and web of Science was performed to identify relevant studies up to January 25, 2020.
Results: A total of 39 eligible studies including 15 studies with 2274 cases and 1933 controls on VNTR 4b/a, nine studies with 1640 cases and 1268 controls on -786C > T, and 15 studies with 2660 cases and 2557 controls on + 894G > T polymorphism were selected. Pooled data revealed that eNOS VNTR 4b/a (dominant model: OR = 1.174, 95% CI 1.021-1.350, p = 0.025) and + 894G > T (allele model: OR = 1.278, 95% CI 1.024-1.595, p = 0.030; homozygote model: OR = 1.442, 95% CI 1.084-1.917, p = 0.012; dominant model: OR = 1.305, 95% CI 1.006-1.693, p = 0.045; and recessive model: OR = 1.378, 95% CI 1.045-1.817, p = 0.023) polymorphisms were significantly associated with an increased risk of RPL, but not  - 786 T > C. Stratified analysis by ethnicity revealed that the eNOS + 894G > T was associated with RPL risk in Asians.
Conclusions: To sum up, our results indicated that the eNOS VNTR 4b/a and + 894G > T polymorphisms might be contributing to RPL development, but not the  - 786C > T polymorphism.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: