Liraglutide reduces cardiac adipose tissue in type 2 diabetes: A secondary analysis of the LIRAFLAME randomized placebo-controlled trial.

Autor: Rasmussen IKB; Steno Diabetes Centre Copenhagen, Gentofte, Denmark., Zobel EH; Steno Diabetes Centre Copenhagen, Gentofte, Denmark., Ripa RS; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Kobenhavn, Denmark.; University of Copenhagen, Copenhagen, Denmark., von Scholten BJ; Steno Diabetes Centre Copenhagen, Gentofte, Denmark.; Novo Nordisk A/S, Søborg, Denmark., Curovic VR; Steno Diabetes Centre Copenhagen, Gentofte, Denmark., Jensen JK; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Kobenhavn, Denmark.; University of Copenhagen, Copenhagen, Denmark., Kjaer A; Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Kobenhavn, Denmark.; University of Copenhagen, Copenhagen, Denmark., Hansen TW; Steno Diabetes Centre Copenhagen, Gentofte, Denmark., Rossing P; Steno Diabetes Centre Copenhagen, Gentofte, Denmark.; University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2021 Dec; Vol. 23 (12), pp. 2651-2659. Date of Electronic Publication: 2021 Aug 26.
DOI: 10.1111/dom.14516
Abstrakt: Aim: To test the hypothesis that treatment with liraglutide can reduce cardiac adipose tissue.
Materials and Methods: LIRAFLAME is a randomized placebo-controlled, double-blind, parallel clinical study. Participants with type 2 diabetes were randomized to treatment with liraglutide 1.8 mg/d or placebo for 26 weeks. Computed tomography was performed at baseline and at end of treatment to evaluate the cardiac adipose tissue volume, quantified automatically. We report the results of a secondary endpoint evaluating changes in cardiac adipose tissue.
Results: A total of 102 participants were randomly assigned to liraglutide (n = 51) or placebo (n = 51). At baseline, the mean (SD) cardiac adipose tissue volume was comparable between the liraglutide and the placebo group (232.6 [112.8] vs. 227.0 [103.2] mL; P = 0.80). The mean change in body weight was -3.7 (-4.8, -2.6) kg in the liraglutide and -0.18 (-0.76, 0.40) kg in the placebo group. From baseline to end of treatment the mean cardiac adipose tissue change was -11.5 (95% confidence interval -17.6, -5.4) mL in the liraglutide (P < 0.001) and -0.01 (-5.3, 5.3) mL in the placebo (P = 1.00) groups. The reduction in cardiac adipose tissue was significantly greater in the liraglutide compared to the placebo group (mean difference -11.4 [-19.4, -3.3] mL; P = 0.006), but significance was lost after adjustment for changes in body mass index (P = 0.46).
Conclusion: Treatment with liraglutide for 26 weeks was associated with a reduction in cardiac adipose tissue compared to placebo. The reduction was not independent of weight loss, suggesting that this is not a drug-specific effect.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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