| Autor: |
Yi JZ, Himes RS, Smith RJ, McKee PH, Roberts AA; Department of Dermatology, Eastern Virginia Medical School, Norfolk, VA. RobertAA@EVMS.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Dermatology online journal [Dermatol Online J] 2021 Jun 15; Vol. 27 (6). Date of Electronic Publication: 2021 Jun 15. |
| DOI: |
10.5070/D327654060 |
| Abstrakt: |
5-Fluorouracil (5-FU) is an antineoplastic agent that is used topically to treat actinic keratoses. Although topical 5-FU frequently causes irritant contact dermatitis at the site of application, distant skin reactions are rare and could relate to accidental transfer or systemic absorption of the drug. We present a patient who developed a painful scrotal dermatitis after applying the topical cream to actinic keratoses on his chest. Upon discontinuation of topical 5-FU, the reaction resolved over a four-week period with oral prednisone and topical betamethasone ointment. The patient was re-challenged with topical 5-FU one year later and again developed scrotal pain and erythema similar to the initial reaction. Scrotal dermatitis is a rare adverse effect of topical 5-FU therapy that can be associated with significant distress and disruption of daily activities. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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