In situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) for peripheral nerve interfaces.

Autor: Murbach JM; Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA., Currlin S; Department of Neuroscience, University of Florida, Gainesville, FL 32611, USA., Widener A; Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA., Tong Y; Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA., Chhatre S; Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA., Subramanian V; Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA., Martin DC; Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA., Johnson BN; Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA., Otto KJ; Department of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Neuroscience, University of Florida, Gainesville, FL 32611, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA.
Jazyk: angličtina
Zdroj: MRS communications [MRS Commun] 2018 Sep; Vol. 8 (3), pp. 1043-1049. Date of Electronic Publication: 2018 Aug 08.
DOI: 10.1557/mrc.2018.138
Abstrakt: The goal of this study was to perform in situ electrochemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) in peripheral nerves to create a soft, precisely located injectable conductive polymer electrode for bi-directional communication. Intraneural PEDOT polymerization was performed to target both outer and inner fascicles via custom fabricated 3D printed cuff electrodes and monomer injection strategies using a combination electrode-cannula system. Electrochemistry, histology, and laser light sheet microscopy revealed the presence of PEDOT at specified locations inside of peripheral nerve. This work demonstrates the potential for using in situ PEDOT electrodeposition as an injectable electrode for recording and stimulation of peripheral nerves.
Databáze: MEDLINE
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