Association of serum retinol concentration with normal-tension glaucoma.

Autor:	Pang R; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Feng S; Departments of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Cao K; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Sun Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Guo Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Ma D; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Liu X; Departments of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Qian J; Departments of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Xie Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Shi Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., He H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Peng J; Hangzhou Biozon Medical Lab Co Ltd, Hangzhou, China., Chen C; Hangzhou Biozon Medical Lab Co Ltd, Hangzhou, China., Cui J; Physical Examination Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Labisi SA; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Zhang Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Fu Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Li J; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wan Y; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Xin C; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Liu H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Zhang Q; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Weinreb RN; Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA., Wang H; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wang N; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. wningli@vip.163.com.
Jazyk:	angličtina
Zdroj:	Eye (London, England) [Eye (Lond)] 2022 Sep; Vol. 36 (9), pp. 1820-1825. Date of Electronic Publication: 2021 Aug 12.
DOI:	10.1038/s41433-021-01740-6
Abstrakt:	Objectives: To evaluate the association between serum retinol concentration and normal-tension glaucoma (NTG). Methods: A total of 345 study subjects were recruited in a prospective cross-sectional study: 101 patients with NTG, 106 patients with high-pressure primary open-angle glaucoma (POAG) and 138 healthy control subjects. Serum retinol concentration in fasting blood samples was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). All study subjects were given complete ophthalmic examinations and diagnosed by two glaucoma sub-specialists. Results: Serum retinol concentrations in NTG, POAG, and controls were 338.90 ± 103.23 ng/mL, 405.22 ± 114.12 ng/mL, and 408.84 ± 122.36 ng/mL respectively. NTG patients had lower serum retinol concentrations than POAG (p < 0.001) or healthy controls (p < 0.001). There was no statistical difference between the POAG and healthy controls (p = 0.780). Higher proportion of NTG patients (37.6%) than POAG (17.9%) or controls (21.7%) had serum retinol concentrations lower than 300 ng/mL. Serum retinol was positively correlated with optic nerve sheath diameter (ONSD) (r = 0.349, p = 0.001) in glaucoma patients and not associated with any other demographic features or ophthalmic biometric parameters in the NTG patients. Multivariate logistic regression showed that serum retinol (OR = 0.898, 95CI%: 0.851-0.947) was associated with incident NTG. Conclusions: NTG patients had lower serum retinol concentrations. Serum retinol uniquely associated with NTG makes it a new potential option for the diagnosis and treatment of the disease. (© 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)
Databáze:	MEDLINE
Externí odkaz:	Full text from SpringerLink