Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia.
| Autor: | Moon JY; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA., Garg I; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA., Cui Y; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA.; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People's Republic of China., Katz R; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA., Zhu Y; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA.; Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China., Le R; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA.; Wenzhou Medical University affiliated Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China., Lu Y; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA., Lu ES; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA., Ludwig CA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Elze T; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA., Wu DM; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Eliott D; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Miller JW; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Kim LA; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, USA., Husain D; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Vavvas DG; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA., Miller JB; Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA john_miller@meei.harvard.edu.; Harvard Retinal Imaging Lab, Boston, Massachusetts, USA. |
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| Jazyk: | angličtina |
| Zdroj: | The British journal of ophthalmology [Br J Ophthalmol] 2023 Jan; Vol. 107 (1), pp. 102-108. Date of Electronic Publication: 2021 Aug 12. |
| DOI: | 10.1136/bjophthalmol-2021-319540 |
| Abstrakt: | Background/aims: Pathological myopia (PM) is a leading cause of blindness worldwide. We aimed to evaluate microvascular and chorioretinal changes in different stages of myopia with wide-field (WF) swept-source (SS) optical coherence tomography angiography (OCTA). Methods: This prospective cross-sectional observational study included 186 eyes of 122 patients who had undergone imaging between November 2018 and October 2020. Vessel density (VD) and vessel skeletonised density (VSD) of superficial capillary plexus, deep capillary plexus and whole retina, as well as foveal avascular zone parameters, retinal thickness (RT) and choroidal thickness (CT), were calculated. Results: This study evaluated 75 eyes of 48 patients with high myopia (HM), 43 eyes of 31 patients with mild to moderate myopia and 68 eyes of 53 age-matched controls. Controlling for age and the presence of systemic hypertension, we found that HM was associated with decrease in VD and VSD in all layers on 12×12 mm² scans. Furthermore, HM was associated with a VD and VSD decrease in every Early Treatment Diabetic Retinopathy Study grid, with a larger decrease temporally (β Conclusion: Using WF SS-OCTA, we identified reduction in microvasculature and structural changes associated with myopia. Decrease in VD and VSD was greater in the temporal quadrant, and reductions in RT and CT were uneven across the retina. Further work may help identify risk factors for the progression of PM and associated vision-threatening complications. Competing Interests: Competing interests: DMW holds a patent through Massachusetts Eye and Ear (MEE). DE is a consultant for Alcon, Allergan, Dutch Ophthalmic, Glaukos and Alderya Therapeutics. He has a financial relationship with Alderya Therapeutics and Pykus Therapeutics and has received financial support from Neurotech Pharmaceuticals. JWM is a consultant for Heidelberg Engineering, Genetech/Roche, Sunovion, KalVista Pharmaceuticals and ONL Therapeutics. She holds a patent through and has received financial support from ONL, Valeant Pharmaceuticals/MEE and has received financial support from Lowy Medical Research Institute, Ltd. She holds a non-remunerative position at Drusolv Therapeutics. LAK has received financial support from National Eye Institute and CureVac AG and has financial arrangement with Pykus Therapeutics. DH is a consultant for Allergan, Genetech and Omeicos Ophthalmics. She has received financial support from Lions VisionGift, Commonwealth Grant and the Macular Society. DGV is a consultant for Valitor, Olix Pharmaceuticals and has received financial support from National Eye Institute, Research to Prevent Blindness, Loefflers Family Foundation, Yeatts Family Foundation and Alcon Research Institute. JBM is a consultant for Alcon, Allergan, Carl Zeiss, Sunovion and Genentech. (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.) |
| Databáze: | MEDLINE |
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