Polymorphisms at the IL17A and IL17RA Genes are Associated with Prognosis of Papillary Thyroid Carcinoma.

Autor: Bertol BC; Postgraduate Program of Basic and Applied Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, Brazil., Góes de Araújo JN; Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal-RN, Brazil., de Carvalho KTC; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal-RN, Brazil., Gonzaga Dos Santos M; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal-RN, Brazil., Martelli-Palomino G; Department of Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo. Ribeirão Preto-SP, Brazil., de Figueiredo Feitosa NL; Department of Medicine, Division of Endocrinology and Metabolism, Ribeirão Preto Medical School, University of São Paulo. Ribeirão Preto-SP, Brazil., Maciel LMZ; Department of Medicine, Division of Endocrinology and Metabolism, Ribeirão Preto Medical School, University of São Paulo. Ribeirão Preto-SP, Brazil., Silbiger VN; Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal-RN, Brazil; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal-RN, Brazil., Lucena-Silva N; Department of Immunology, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife-PE, Brazil., Freitas JCOC; Postgraduate Program of Pharmaceutical Sciences, Federal University of Rio Grande do Norte, Natal-RN, Brazil; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal-RN, Brazil., Donadi EA; Postgraduate Program of Basic and Applied Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto-SP, Brazil; Department of Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo. Ribeirão Preto-SP, Brazil.
Jazyk: angličtina
Zdroj: Archives of medical research [Arch Med Res] 2022 Feb; Vol. 53 (2), pp. 163-169. Date of Electronic Publication: 2021 Aug 09.
DOI: 10.1016/j.arcmed.2021.07.004
Abstrakt: Background: Interleukin (IL)-17A has a dual role in tumor immunity, promotes anti-tumor responses and facilitates angiogenesis by interacting with IL-17 receptor A (IL-17RA). Although IL-17A has been associated with the pathogenesis of papillary thyroid carcinoma (PTC), the nucleotide variability at the IL17A and IL17RA genes is still poorly characterized.
Aim: To assess the contribution of the IL17A (-197 G >A, rs2275913) and IL17RA (-947 A >G, rs4819554) single nucleotide polymorphisms (SNP) on the development and progression of PTC and on IL-17 plasma levels.
Methods: We studied 188 PTC patients and 170 healthy controls. SNPs were identified using PCR-amplified DNA and restriction fragment length polymorphism (RFLP) techniques. Plasma levels of IL-17A was evaluated in 83 PTC patients using ELISA. Statistical analyses were performed to evaluate the associations between SNPs and clinicohistopathological features of PTC and IL-17A levels.
Results: No significant difference was observed regarding the allele and genotype distributions of both SNPs between PTC patients and controls. The IL17A GA was associated with poor biochemical and structural incomplete response to therapy, whereas no influence over the IL-17A expression was observed. The IL17RA AG was significantly associated with small-sized tumors, initial tumor stage at diagnosis and better response to therapy.
Conclusions: The IL17A SNP may predict an aggressive manifestation of PTC, whereas the IL17RA SNP was associated with a more favorable clinical outcome.
Competing Interests: Competing Interest Authors have no financial disclosure
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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