Functional Vision in the Real-World Environment With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis.

Autor:	Karapanos L; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC, Australia., Abbott CJ; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC, Australia., Ayton LN; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC, Australia.; Department of Optometry and Vision Sciences, University of Melbourne, Melbourne, VIC, Australia., Kolic M; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia., McGuinness MB; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia.; Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia., Baglin EK; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia., Titchener SA; Bionics Institute, East Melbourne, VIC, Australia.; Medical Bionics Department, University of Melbourne, Parkville, VIC, Australia., Kvansakul J; Bionics Institute, East Melbourne, VIC, Australia.; Medical Bionics Department, University of Melbourne, Parkville, VIC, Australia., Johnson D; Specialised Orientation and Mobility, Melbourne, VIC, Australia., Kentler WG; Department of Biomedical Engineering, University of Melbourne, Parkville, VIC, Australia., Barnes N; Research School of Engineering, Australian National University, Canberra, ACT, Australia., Nayagam DAX; Bionics Institute, East Melbourne, VIC, Australia.; Department of Pathology, University of Melbourne, St. Vincent's Hospital, Fitzroy, VIC, Australia., Allen PJ; Centre for Eye Research Australia, Royal Victorian Eye & Ear Hospital, East Melbourne, VIC, Australia.; Ophthalmology, Department of Surgery, University of Melbourne, East Melbourne, VIC, Australia., Petoe MA; Bionics Institute, East Melbourne, VIC, Australia.; Medical Bionics Department, University of Melbourne, Parkville, VIC, Australia.
Jazyk:	angličtina
Zdroj:	Translational vision science & technology [Transl Vis Sci Technol] 2021 Aug 12; Vol. 10 (10), pp. 7.
DOI:	10.1167/tvst.10.10.7
Abstrakt:	Purpose: In a clinical trial (NCT03406416) of a second-generation (44-channel) suprachoroidal retinal prosthesis implanted in subjects with late-stage retinitis pigmentosa (RP), we assessed performance in real-world functional visual tasks and emotional well-being. Methods: The Functional Low-Vision Observer Rated Assessment (FLORA) and Impact of Vision Impairment-Very Low Vision (IVI-VLV) instruments were administered to four subjects before implantation and after device fitting. The FLORA contains 13 self-reported and 35 observer-reported items ranked for ease of conducting task (impossible-easy, central tendency given as mode). The IVI-VLV instrument quantified the impact of low vision on daily activities and emotional well-being. Results: Three subjects completed the FLORA for two years after device fitting; the fourth subject ceased participation in the FLORA after fitting for reasons unrelated to the device. For all subjects at each post-fitting visit, the mode ease of task with device ON was better or equal to device OFF. Ease of task improved over the first six months with device ON, then remained stable. Subjects reported improvements in mobility, functional vision, and quality of life with device ON. The IVI-VLV suggested self-assessed vision-related quality of life was not impacted by device implantation or usage. Conclusions: Subjects demonstrated sustained improved ease of task scores with device ON compared to OFF, indicating the device has a positive impact in the real-world setting. Translational Relevance: Our suprachoroidal retinal prosthesis shows potential utility in everyday life, by enabling an increased environmental awareness and improving access to sensory information for people with end-stage RP.
Databáze:	MEDLINE
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