Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function.

Autor:	Tan J; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Ni D; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Wali JA; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia., Cox DA; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Pinget GV; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Taitz J; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Daïen CI; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; CHRU Montpellier, Département de Rhumatologie, Montpellier FRANCE & University of Montpellier, PhyMedExp, INSERM, CNRS UMR, Montpellier, France., Senior A; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia.; School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia., Read MN; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Computer Science, Faculty of Engineering, University of Sydney, Sydney, NSW, Australia.; The Westmead Initiative, Faculty of Engineering, The University of Sydney, Sydney, NSW, Australia., Simpson SJ; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia., King NJC; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Pathology School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Sydney Cytometry, The University of Sydney and The Centenary Institute, Sydney, NSW, Australia., Macia L; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.; Discipline of Physiology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Jul 10; Vol. 24 (8), pp. 102835. Date of Electronic Publication: 2021 Jul 10 (Print Publication: 2021).
DOI:	10.1016/j.isci.2021.102835
Abstrakt:	While diet modulates immunity, its impact on B cell ontogeny remains unclear. Using mixture modeling, a large-scale isocaloric dietary cohort mouse study identified carbohydrate as a major driver of B cell development and function. Increasing dietary carbohydrate increased B cell proportions in spleen, mesenteric lymph node and Peyer's patches, and increased antigen-specific immunoglobulin G production after immunization. This was linked to increased B lymphopoiesis in the bone marrow. Glucose promoted early B lymphopoiesis and higher total B lymphocyte numbers than fructose. It drove B cell development through glycolysis and oxidative phosphorylation, independently of fatty acid oxidation in vitro and reduced B cell apoptosis in early development via mTOR activation, independently of interleukin-7. Ours is the first comprehensive study showing the impact of macronutrients on B cell development and function. It shows the quantitative and qualitative interplay between dietary carbohydrate and B cells and argues for dietary modulation in B cell-targeting strategies. Competing Interests: The authors declare no competing interests. (© 2021 The Authors.)
Databáze:	MEDLINE
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