Systematic reviews on interventions for COVID-19 have rarely graded the certainty of the evidence.

Autor:	Martimbianco ALC; PhD. Professor, Centro Universitário São Camilo, São Paulo (SP), Brazil; and Professor, Universidade Metropolitana de Santos (UNIMES), Santos (SP), Brazil., Pacheco RL; MSc. Professor, Centro Universitário São Camilo, São Paulo (SP), Brazil; and Researcher, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo (SP), Brazil., Latorraca COC; MSc. Researcher, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo (SP), Brazil., Ferreira RES; PhD. Professor, Centro Universitário São Camilo, São Paulo (SP), Brazil., Riera R; PhD. Adjunct Professor, Discipline of Evidence-Based Health, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-UNIFESP), São Paulo (SP), Brazil; and Coordinator, Health Technology Assessment Center, Hospital Sírio-Libanês, São Paulo (SP), Brazil.
Jazyk:	angličtina
Zdroj:	Sao Paulo medical journal = Revista paulista de medicina [Sao Paulo Med J] 2021 Aug-Sep; Vol. 139 (5), pp. 511-513.
DOI:	10.1590/1516-3180.2021.0107.27052021
Abstrakt:	Background: Numerous systematic reviews on coronavirus disease-19 (COVID-19) treatment have been developed to provide syntheses of the large volume of primary studies. However, the methodological quality of most of these reviews is questionable and the results provided may therefore present bias. Objective: To investigate how many systematic reviews on the therapeutic or preventive options for COVID-19 assessed the certainty of the evidence through the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Methods: We conducted a sensitive search in MEDLINE (via PubMed) and included all systematic reviews that assessed any intervention for COVID-19. The systematic reviews included were examined to identify any planned and/or actual assessment using the GRADE approach (or absence thereof) regarding the certainty of the evidence. Results: We included 177 systematic reviews and found that only 37 (21%; 37/177) assessed and reported the certainty of the evidence using the GRADE approach. This number reduced to 27 (16.2%; 27/167) when Cochrane reviews (n = 10), in which an evaluation using GRADE is mandatory, were excluded. Conclusion: Most of the systematic reviews on interventions relating to COVID-19 omitted assessment of the certainty of the evidence. This is a critical methodological omission that must not be overlooked in further research, so as to improve the impact and usefulness of syntheses relating to COVID-19.
Databáze:	MEDLINE
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