Short-term outcome after open-heart surgery for severe chronic rheumatic heart disease in a low-income country, with comparison with an historical control group: an observational study.

Autor:	Hauge SW; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway stalewhauge@gmail.com.; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Clinic of Cardiology, St Olavs University Hospital, Trondheim, Norway., Dalen H; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.; Clinic of Cardiology, St Olavs University Hospital, Trondheim, Norway.; Department of Medicine, Levanger Hospital, Levanger, Norway., Estensen ME; Department of Cardiology, Oslo University Hospital, Oslo, Norway., Persson RM; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Hordaland, Norway., Abebe S; Department of Cardiology, School of Medicine, Addis Ababa University College of Health Sciences, Addis Ababa, Oromia, Ethiopia., Mekonnen D; Department of Cardiology, School of Medicine, Addis Ababa University College of Health Sciences, Addis Ababa, Oromia, Ethiopia., Nega B; Department of Surgery, School of Medicine, Addis Ababa University College of Health Sciences, Addis Ababa, Oromia, Ethiopia., Solholm A; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway., Farstad M; Department of Surgical Services, Haukeland University Hospital, Bergen, Norway., Bogale N; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway., Graven T; Department of Medicine, Levanger Hospital, Levanger, Norway., Nielssen NE; Clinic of Cardiology, Linköping University Hospital, Linköping, Sweden., Brekke HK; Department of Surgical Services, Haukeland University Hospital, Bergen, Norway., Vikenes K; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Hordaland, Norway., Haaverstad R; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Hordaland, Norway.
Jazyk:	angličtina
Zdroj:	Open heart [Open Heart] 2021 Aug; Vol. 8 (2).
DOI:	10.1136/openhrt-2021-001706
Abstrakt:	Objectives: Rheumatic heart disease (RHD) is a major burden in low-income and middle-income countries (LMICs). Cardiac surgery is the only curative treatment. Little is known about patients with severe chronic RHD operated in LMICs, and challenges regarding postoperative follow-up are an important issue. At Tikur Anbessa Specialised Hospital, Addis Ababa, Ethiopia, we aimed to evaluate the course and 12-month outcome of patients with severe chronic RHD who received open-heart surgery, as compared with the natural course of controls waiting for surgery and undergoing only medical treatment. Methods: Clinical data and outcome measures were registered in 46 patients operated during five missions from March 2016 to November 2019, and compared with the first-year course in a cohort of 49 controls from the same hospital's waiting list for surgery. Adverse events were death or complications such as stroke, other thromboembolic events, bleeding, hospitalisation for heart failure and infectious endocarditis. Results: Survival at 12 months was 89% and survival free from complications was 80% in the surgical group. Despite undergoing open-heart surgery, with its inherent risks, outcome measures of the surgical group were non-inferior to the natural course of the control group in the first year after inclusion on the waiting list (p≥0.45). All except six surgical patients were in New York Heart Association class I after 12 months and 84% had resumed working. Conclusions: Cardiac surgery for severe chronic RHD is feasible in LMICs if the service is structured and planned. Rates of survival and survival free from complications were similar to those of controls at 12 months. Functional level and resumption of work were high in the surgical group. Whether the patients who underwent cardiac surgery will have better long-term prognosis, in line with what is known in high-income countries, needs to be evaluated in future studies. Competing Interests: Competing interests: HD and SWH hold positions at the Centre of Innovative Ultrasound Solutions at the Norwegian University of Science and Technology, where GE Ultrasound is an institutional partner. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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