The promoting effect of vagus nerve stimulation on Lempel-Ziv complexity index of consciousness.

Autor: Salemi-Mokri-Boukani P; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Karimian-Sani-Varjovi H; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Brain Future Institute, Tehran, Iran., Safari MS; Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Brain Future Institute, Tehran, Iran. Electronic address: safari@sbmu.ac.ir.
Jazyk: angličtina
Zdroj: Physiology & behavior [Physiol Behav] 2021 Oct 15; Vol. 240, pp. 113553. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.physbeh.2021.113553
Abstrakt: Recent studies suggest that vagus nerve stimulation (VNS) promotes cognitive and behavioral restoration after traumatic brain injuries. As vagus nerve has wide effects over the brain and visceral organs, stimulation of the sensory/visceral afferents might have a therapeutic potential to modulate the level of consciousness. One of the most important challenges in studying consciousness is objective evaluation of the consciousness level. Brain complexity that can be measured through Lempel-Ziv complexity (LZC) index was used as a novel mathematical approach for objective measurement of consciousness. The main goal of our study was to examine the effects of VNS on LZC index of consciousness. In this study, we did VNS on the anesthetized rats, and simultaneously LFPs recording was performed in two different cortical areas of primary somatosensory (S 1 ) or visual (V 1 ) cortex. LZC and the amplitude of slow waves were computed during different periods of VNS. We found that the LZC index during VNS period was significantly higher in both of the cortical areas of S 1 and V 1 . Slow-wave activity decreased during VNS in S 1 , while there was no significant change in V 1 . Our findings showed that VNS can augment the consciousness level, and LZC index is a more sensitive parameter for detecting the level of consciousness.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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