Pulmonary function of healthy Korean children from three independent birth cohorts: Validation of the Global Lung Function Initiative 2012 equation.

Autor: Park JS; Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Suh DI; Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Choi YJ; Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Ahn K; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, Seoul, Republic of Korea., Kim KW; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea., Shin YH; Department of Pediatrics, CHA Gangnam Medical Center, School of Medicine, CHA University, Seoul, Republic of Korea., Lee SY; Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Cho HJ; Department of Pediatrics, International St. Mary's Hospital, Catholic Kwandong University Hospital, Incheon, Republic of Korea., Lee E; Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea., Jang GC; Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea., Kwon JW; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Sun YH; Department of Pediatrics, Gachon University Gil Medical Center, Incheon, Republic of Korea., Woo SI; Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea., Youn YS; Departments of Pediatrics, College of Medicine, The Catholic University of Korea, Daejeon, Republic of Korea., Park KS; Department of Pediatrics, Presbyterian Medical Center, Jeonju, Republic of Korea., Kook MH; Department of Pediatrics, Gwangju Veterans Hospital, Gwangju, Republic of Korea., Cho HJ; Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea., Chung HL; Department of Pediatrics, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea., Kim JH; Department of Pediatrics, Ulsan University Hospital, Ulsan, Republic of Korea., Kim HY; Department of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea., Jung JA; Department of Pediatrics, Anatomy, College of Medicine, Dong-A University, Busan, Republic of Korea., Woo HO; Departments of Pediatrics, Gyeongsang National University College of Medicine, Jinju, Republic of Korea., Choi YK; Korea Institute of Child Care and Education, Seoul, Republic of Korea., Lee JR; Korea Institute of Child Care and Education, Seoul, Republic of Korea., Lee YA; Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Shin CH; Department of Pediatrics, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim BN; Department of Psychiatry, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea., Kim JI; Department of Psychiatry, Hanyang University Medical Center, Seoul, Republic of Korea., Lee KS; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Lim YH; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea., Hong YC; Environmental Health Center, Seoul National University College of Medicine, Seoul, Republic of Korea.; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea., Hong SJ; Department of Pediatrics, Childhood Asthma Atopy Center, Humidifier Disinfectant Health Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Jazyk: angličtina
Zdroj: Pediatric pulmonology [Pediatr Pulmonol] 2021 Oct; Vol. 56 (10), pp. 3310-3320. Date of Electronic Publication: 2021 Aug 25.
DOI: 10.1002/ppul.25622
Abstrakt: Background and Objective: Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children.
Methods: Spirometry indices (FEV1, FVC, FEV1/FVC, and FEF25%-75%) and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z scores were compared with the expected 0 and 1. Probabilities of falling below the lower limit of normal (LLN) (z score: -1.64) were compared with the expected value 5%. GLI z scores were assessed according to low (<-2), normal (≥-2 and ≤2), and high (>2) BMI z score groups.
Results: Mean z scores significantly differed from 0 for FEV1/FVC in males (mean [95% confidence interval]: 0.18 [0.08, 0.27]) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5% for FEV1 (12.13% [9.64, 14.77]), FVC (15.86% [13.06, 18.81]), and forced expiratory flow at 25%-75% of forced vital capacity (FEF25%-75%) (7.31% [5.29, 9.49]) in males and FVC (11.91% [9.40, 14.60]) in females. FEV1 and FVC z scores increased across low to high body mass index (BMI) groups, and FEV1/FVC decreased from low to high BMI groups.
Conclusion: GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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