Varicella-Zoster Virus-Genetics, Molecular Evolution and Recombination.
| Autor: | Depledge DP; Institute of Virology, Hannover Medical School (MHH), Hannover, Germany. depledge.daniel@mh-hannover.de.; Department of Microbiology, NYU School of Medicine, New York, USA. depledge.daniel@mh-hannover.de., Breuer J; Department of Infection & Immunology, University College London, London, UK. |
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| Jazyk: | angličtina |
| Zdroj: | Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2023; Vol. 438, pp. 1-23. |
| DOI: | 10.1007/82_2021_238 |
| Abstrakt: | This chapter first details the structure, organization and coding content of the VZV genome to provide a foundation on which the molecular evolution of the virus can be projected. We subsequently describe the evolution of molecular profiling approaches from restriction fragment length polymorphisms to single nucleotide polymorphism profiling to modern day high-throughput sequencing approaches. We describe how the application of these methodologies led to our current model of VZV phylogeograpy including the number and structure of geographic clades and the role of recombination in reshaping these. (© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.) |
| Databáze: | MEDLINE |
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