Age and sex distribution of Mycobacterium tuberculosis infection and rifampicin resistance in Myanmar as detected by Xpert MTB/RIF.

Autor: Seifert M; University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA. mseifert@ucsd.edu., Aung HT; Clinton Health Access Initiative, Yangon, Myanmar., Besler N; University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA., Harris V; FIND, the global alliance for diagnostics, Campus Biotech, 9 Chemin des Mines -, 1202, Geneva, Switzerland., Mar TT; Ministry of Health and Sports, Office No. 4, Naypyitaw, Myanmar., Colman RE; University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA., Rodwell TC; University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA., Aung ST; Ministry of Health and Sports, Office No. 4, Naypyitaw, Myanmar.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2021 Aug 09; Vol. 21 (1), pp. 781. Date of Electronic Publication: 2021 Aug 09.
DOI: 10.1186/s12879-021-06296-0
Abstrakt: Background: Detection of tuberculosis disease (TB) and timely identification of Mycobacterium tuberculosis (Mtb) strains that are resistant to treatment are key to halting tuberculosis transmission, improving treatment outcomes, and reducing mortality.
Methods: We used 332,657 Xpert MTB/RIF assay results, captured as part of the Myanmar Data Utilization Project, to characterize Mtb test positivity and rifampicin resistance by both age and sex, and to evaluate risk factors associated with rifampicin resistance.
Results: Overall, 70% of individuals diagnosed with TB were males. Test positivity was higher among males (47%) compared to females (39%). The highest positivity by age occurred among individuals aged 16-20, with test positivity for females (65%) higher than for males (57%). Although a greater absolute number of males were rifampicin resistant, a greater proportion of females (11.4%) were rifampicin resistant as compared to males (9.3%). In the multivariate model, history of previous treatment, age less than 30, testing in the Yangon region, and female sex were significantly positively associated with rifampicin resistance after adjusting for HIV status and year test was performed.
Conclusions: Our results indicate that young adults were more likely to test positive for TB and be identified as rifampicin resistant compared to older adults.
(© 2021. The Author(s).)
Databáze: MEDLINE
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