Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry.

Autor: Large EE; Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA., Silveria MA; Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA., Zane GM; Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA., Weerakoon O; Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA., Chapman MS; Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2021 Jul 10; Vol. 13 (7). Date of Electronic Publication: 2021 Jul 10.
DOI: 10.3390/v13071336
Abstrakt: Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of AAV capsid modification strategies. Significant factors influencing rAAV transduction efficiency include neutralizing antibodies, attachment factor interactions and receptor binding. Advances in understanding the molecular interactions during rAAV cell entry combined with improved capsid modulation strategies will help guide the design and engineering of safer and more efficient rAAV gene therapy vectors.
Databáze: MEDLINE
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