| Autor: |
Yashina LN; State Research Center of Virology and Biotechnology 'Vector', 630559 Koltsovo, Russia., Abramov SA; Institute of Systematics and Ecology of Animals, 630091 Novosibirsk, Russia., Zhigalin AV; Department of Vertebrate Zoology and Ecology, Tomsk State University, 634050 Tomsk, Russia., Smetannikova NA; State Research Center of Virology and Biotechnology 'Vector', 630559 Koltsovo, Russia., Dupal TA; Institute of Systematics and Ecology of Animals, 630091 Novosibirsk, Russia., Krivopalov AV; Institute of Systematics and Ecology of Animals, 630091 Novosibirsk, Russia., Kikuchi F; Center for Infectious Disease Epidemiology and Prevention Research, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan.; Center for Surveillance, Immunization and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Senoo K; Center for Surveillance, Immunization and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan., Arai S; Center for Surveillance, Immunization and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Mizutani T; Center for Infectious Disease Epidemiology and Prevention Research, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan., Suzuki M; Center for Surveillance, Immunization and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Cook JA; Department of Biology and Museum of Southwestern Biology, University of New Mexico, Albuquerque, NM 87131, USA., Yanagihara R; Department of Pediatrics, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA. |
| Abstrakt: |
The discovery of genetically distinct hantaviruses (family Hantaviridae ) in multiple species of shrews, moles and bats has revealed a complex evolutionary history involving cross-species transmission. Seewis virus (SWSV) is widely distributed throughout the geographic ranges of its soricid hosts, including the Eurasian common shrew ( Sorex araneus ), tundra shrew ( Sorex tundrensis ) and Siberian large-toothed shrew ( Sorex daphaenodon ), suggesting host sharing. In addition, genetic variants of SWSV, previously named Artybash virus (ARTV) and Amga virus, have been detected in the Laxmann's shrew ( Sorex caecutiens ). Here, we describe the geographic distribution and phylogeny of SWSV and Altai virus (ALTV) in Asian Russia. The complete genomic sequence analysis showed that ALTV, also harbored by the Eurasian common shrew, is a new hantavirus species, distantly related to SWSV. Moreover, Lena River virus (LENV) appears to be a distinct hantavirus species, harbored by Laxmann's shrews and flat-skulled shrews ( Sorex roboratus ) in Eastern Siberia and far-eastern Russia. Another ALTV-related virus, which is more closely related to Camp Ripley virus from the United States, has been identified in the Eurasian least shrew ( Sorex minutissimus ) from far-eastern Russia. Two highly divergent viruses, ALTV and SWSV co-circulate among common shrews in Western Siberia, while LENV and the ARTV variant of SWSV co-circulate among Laxmann's shrews in Eastern Siberia and far-eastern Russia. ALTV and ALTV-related viruses appear to belong to the Mobatvirus genus, while SWSV is a member of the Orthohantavirus genus. These findings suggest that ALTV and ALTV-related hantaviruses might have emerged from ancient cross-species transmission with subsequent diversification within Sorex shrews in Eurasia. |
