Expression of autophagy related genes in peripheral blood cells in Parkinson's disease.

Autor: Tu HY; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China., Gu YQ; Department of Neurology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China., Li X; Department of Neurology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China., Pei SF; Department of Neurology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China., Hu LF; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: hulifang@suda.cn., Wang YL; Department of Neurology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215000, China. Electronic address: yjyali@sina.com.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2021 Sep 25; Vol. 762, pp. 136166. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.neulet.2021.136166
Abstrakt: Parkinson's disease (PD) is the second most common neurodegenerative disorder and affects dopaminergic neurons. Autophagy often shows a circadian rhythm pattern under physiological conditions across 24 h. Abnormal autophagy and circadian dysfunction are two characteristics of PD. Whether the rhythm of autophagy is altered in PD has not yet been reported. Therefore, in this study, we collected peripheral blood samples at 6:00 h and 18:00 h from PD patients and age-matched controls, and analyzed the mRNA expressions of ULK1, BECN1, LAMP2, AMPK, and SNCA using real-time quantitative PCR. Blood samples analysis found that BECN1 and LAMP2 levels were decreased in patients with PD. Simultaneously, the rhythm of autophagy in PD is not consistent with that in the Control group, which may be a manifestation of the abnormal biological rhythm of PD.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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