The effects of Cuminum cyminum on glycemic parameters: A systematic review and meta-analysis of controlled clinical trials.

Autor: Tavakoli-Rouzbehani OM; Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran., Faghfouri AH; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: amir.nut89@gmail.com., Anbari M; Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran., Papi S; Department of Public Health, Faculty of Health, Social Determinants of Health Research Center, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran., Shojaei FS; Department of Medical Sciences, Marand Branch, Islamic Azad University, Marand, Iran., Ghaffari M; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran., Alizadeh M; Department of Clinical Nutrition, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: mdalizadeh@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2021 Dec 05; Vol. 281, pp. 114510. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.jep.2021.114510
Abstrakt: Ethnopharmacological Relevance: Cuminum Cyminum (CC) is a traditional herbal medicine using as an antiseptic, anti-carcinogenic, anti-mutagenic, anti-cancer, anti-hypertensive, anti-inflammatory, and antioxidant. Recently hypoglycemic characteristics of CC have been indicated.
Aim of the Study: We intended to conduct a meta-analysis on the effect of CC supplementation on glycemic parameters in patients with different chronic diseases.
Materials and Methods: PubMed, Embase, Web of Science, and Scopus were searched until May 2021. Random effect model was conducted to perform the meta-analysis. Source of heterogeneity was explored using the meta-regression and subgroup analyses. The Cochrane Collaboration's tool was used to assess the quality of studies. The GRADE approach was used to assess the quality of evidence.
Results: Findings of eight studies showed that CC supplementation reduced FBS (SMD = -1.4 mg/dl; 95 % CI: -2.29, -0.51; P = 0.002), HbA1c (SMD = -1.71 %; 95 % CI: -3.24, -0.18; P = 0.028), and HOMA-β (SMD = 0.46; 95 % CI: -0.62, 1.55; P = 0.404) significantly. Also, CC increased QUICKI level (SMD = 0.89; 95 % CI: 0.37, 1.4; P = 0.001. However, no significant effect of CC was observed on insulin (SMD = -0.70 μIU/dl; 95 % CI: -1.84, 0.45; P = 0.234) and HOMA-IR (SMD = 0.46; 95 % CI: -0.62, 1.55; P = 0.404).
Conclusion: CC had an improving effect on FBS, HbA1C, HOMA-B, and QUICKI. The effect of CC on amending HOMA-IR was significant after sensitivity analysis. However, the insulin level was not changed significantly.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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