Biomimetic immunomodulation strategies for effective tissue repair and restoration.

Autor: Villarreal-Leal RA; Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA; Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ave. Morones Prieto 3000, Monterrey, Nuevo León 64710, México., Healey GD; Institute for Life Science, Swansea University Medical School, Singleton Park, Swansea SA2 8PP, UK., Corradetti B; Department of Nanomedicine, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA; Institute for Life Science, Swansea University Medical School, Singleton Park, Swansea SA2 8PP, UK; Texas A&M Health Science Center, College of Medicine, 8441 Riverside Pkwy, Bryan, TX 77807, USA. Electronic address: bcorradetti2@houstonmethodist.org.
Jazyk: angličtina
Zdroj: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2021 Dec; Vol. 179, pp. 113913. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1016/j.addr.2021.113913
Abstrakt: Inflammation plays a central role in wound healing following injury or disease and is mediated by a precise cascade of cellular and molecular events. Unresolved inflammatory processes lead to chronic inflammation and fibrosis, which can result in prolonged wound healing lasting months or years that hampers tissue function. Therapeutic interventions mediated by immunomodulatory drugs, cells, or biomaterials, are therefore most effective during the inflammatory phase of wound healing when a pro-regenerative environment is essential. In this review, we discuss the advantages of exploiting knowledge of the native tissue microenvironment to develop therapeutics capable of modulating the immune response and promoting functional tissue repair. In particular, we provide examples of the most recent biomimetic platforms proposed to accomplish this goal, with an emphasis on those able to induce macrophage polarization towards a pro-regenerative phenotype.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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