The kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis.

Autor: Phuc LDV; Medic Medical Center, Ho Chi Minh City, Vietnam., Hai TX; Department of Otorhinolaryngology, Nghe An Obstetrics and Pediatrics Hospital, Vinh, Nghe An, Vietnam., Loi CB; Scientific and Training Management Department, National Institute of Malaria, Parasitology and Entomology of Vietnam, Ha Noi, Vietnam., Quang HH; Institute of Malariology, Parasitology and Entomology, Binh Dinh, Vietnam., Vinh LD; Medical Parasitology Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Le TA; Department of Parasitology, Vietnam Military Medical University, Ha Noi, Vietnam.
Jazyk: angličtina
Zdroj: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2021 Nov; Vol. 26 (11), pp. 1419-1426. Date of Electronic Publication: 2021 Aug 16.
DOI: 10.1111/tmi.13665
Abstrakt: Objectives: Human toxocariasis is a widespread zoonosis for which a chemotherapy decision and therapy effectiveness are difficult to determine. We aimed to investigate the kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis in Vietnam.
Methods: The prospective study was conducted between October 2017 and June 2019. The diagnosis of toxocariasis was established based on clinical, laboratory (eosinophilia, raised IgE concentration) and serological (positive Toxocara IgG ELISA) evaluation as well as the exclusion of another helminthic co-infection. The patients were followed up after seven days, then one, three and six months after chemotherapy by thiabendazole.
Results: The study involved 80 patients with a mean age of 41.6 ± 15.2 years of whom 58.8% were female. At three and six months after chemotherapy, most patients demonstrated resolution of clinical signs and symptoms, eosinophil count and IgE concentration but not in the proportion of IgG seropositivity. Skin lesions and eosinophilia resolved earlier than the other symptoms (one month after treatment). About four-fifths of the patients were "cured" after three and six months of follow-up; 33.8% showed side effects to thiabendazole therapy but no severe events were reported. The most common adverse reaction was neurologic symptoms followed by gastrointestinal or skin manifestations which lasted as long as 4 days.
Conclusions: In toxocariasis patients, cutaneous manifestations and eosinophilia resolve more rapidly than other clinical and laboratory findings while IgG titre has a very slow kinetic after therapy. Thiabendazole seems to be a potential alternative for the treatment of human toxocariasis.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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