The Participation of a Malignant Catarrhal Fever Virus and Mycoplasma bovis in the Development of Single and Mixed Infections in Beef and Dairy Cattle With Bovine Respiratory Disease.

Autor:	Oliveira TES; Laboratory of Animal Pathology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil.; National Institutes of Science and Technology, Dairy Production Chain (INCT-Leite), Universidade Estadual de Londrina, Londrina, Brazil., Scuisato GS; Laboratory of Animal Pathology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil., Pelaquim IF; Laboratory of Animal Pathology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil., Cunha CW; Animal Disease Research Unit, Agricultural Research Service, United States Department of Agriculture, Pullman, WA, United States.; Department of Veterinary Microbiology and Pathology and Paul G. Alan School for Global Animal Health, Washington State University, Pullman, WA, United States., Cunha LS; Department of Statistics, Universidade Estadual de Londrina, Londrina, Brazil., Flores EF; Department of Preventive Veterinary Medicine, Universidade Federal de Santa Maria, Santa Maria, Brazil., Pretto-Giordano LG; Laboratory of Veterinary Microbiology and Infectious Diseases, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Brazil., Lisbôa JAN; National Institutes of Science and Technology, Dairy Production Chain (INCT-Leite), Universidade Estadual de Londrina, Londrina, Brazil.; Large Animal Internal Medicine, Department of Veterinary Clinics, Universidade Estadual de Londrina, Londrina, Brazil., Alfieri AA; National Institutes of Science and Technology, Dairy Production Chain (INCT-Leite), Universidade Estadual de Londrina, Londrina, Brazil.; Laboratory of Animal Virology, Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Brazil., Saut JPE; Large Animal Health Laboratory, Universidade Federal de Uberlândia, Uberlândia, Brazil., Jorge da Cunha PH; Veterinary Medicine Department, Universidade Federal de Goiás, Goiânia, Brazil., Headley SA; Laboratory of Animal Pathology, Department of Veterinary Preventive Medicine, Universidade Estadual de Londrina, Londrina, Brazil.; National Institutes of Science and Technology, Dairy Production Chain (INCT-Leite), Universidade Estadual de Londrina, Londrina, Brazil.; Programa de Pós-Graduação em Biociência Animal, Universidade de Cuiabá, Cuiabá, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2021 Jul 22; Vol. 8, pp. 691448. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021).
DOI:	10.3389/fvets.2021.691448
Abstrakt:	The bovine respiratory disease (BRD) complex is a multietiological and multifactorial disease associated with a wide range of viral and bacterial pathogens. This study evaluated the contribution of specific infectious disease agents in the development of BRD in cattle from Brazil and determined if a virus within the malignant catarrhal fever virus (MCFV) group and Mycoplasma bovis , acting individually or in conjunction, can be associated with the development of BRD. Formalin-fixed paraffin-embedded pulmonary sections were used in immunohistochemical assays to determine the intralesional presence of six antigens associated with BRD: bovine alphaherpesvirus 1 (BoHV-1), bovine parainfluenza virus 3 (BPIV-3), bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV), MCFV, and M. bovis . Pneumonia was diagnosed in 82.7% (120/145) of all cattle evaluated. Interstitial pneumonia (60%, 72/120) and suppurative bronchopneumonia (25.8%, 31/120) were the most frequent patterns of pneumonia identified. Intralesional antigens of MCFV (53.3%, 64/120) were the most frequently associated with BRD, followed by M. bovis (47.5%, 57/120), BVDV (42.5%, 51/120), BoHV-1 (28.3%, 34/120), BRSV (24.2%, 29/120), and BPIV-3 (8.3%, 10/120). Additionally, antigens of BVDV, MCFV, and M. bovis were the most frequently identified agents associated with singular and concomitant infections. The MCFV identified during this study is more likely to be ovine gammaherpesvirus 2 (OvHV-2), since OvHV-2 is the only MCFV identified within the geographical region of this study. Interstitial pneumonia with proliferative vascular lesions may be a useful histologic feature to differentiate MCFV-induced pneumonia from other viral pneumonias of cattle. These results demonstrate that MCFV and M. bovis , in single or mixed infections, can produce pneumonia in cattle and should therefore be considered as primary agents in the development of BRD. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Oliveira, Scuisato, Pelaquim, Cunha, Cunha, Flores, Pretto-Giordano, Lisbôa, Alfieri, Saut, Jorge da Cunha and Headley.)
Databáze:	MEDLINE
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