A Comparative Overview of Epigenomic Profiling Methods.
| Autor: | Mehrmohamadi M; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran., Sepehri MH; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran., Nazer N; Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran., Norouzi MR; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Jul 22; Vol. 9, pp. 714687. Date of Electronic Publication: 2021 Jul 22 (Print Publication: 2021). |
| DOI: | 10.3389/fcell.2021.714687 |
| Abstrakt: | In the past decade, assays that profile different aspects of the epigenome have grown exponentially in number and variation. However, standard guidelines for researchers to choose between available tools depending on their needs are lacking. Here, we introduce a comprehensive collection of the most commonly used bulk and single-cell epigenomic assays and compare and contrast their strengths and weaknesses. We summarize some of the most important technical and experimental parameters that should be considered for making an appropriate decision when designing epigenomic experiments. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Mehrmohamadi, Sepehri, Nazer and Norouzi.) |
| Databáze: | MEDLINE |
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