Hypotheses and facts for genetic factors related to severe COVID-19.
| Autor: | Kotsev SV; Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, Pazardzhik 4400, Bulgaria., Miteva D; Department of Genetics, Sofia University 'St. Kliment Ohridski', Sofia 1000, Bulgaria., Krayselska S; Private Practice General Praxis, Sofia 1113, Bulgaria., Shopova M; Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, Pazardzhik 4400, Bulgaria., Pishmisheva-Peleva M; Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, Pazardzhik 4400, Bulgaria., Stanilova SA; Department of Molecular Biology, Immunology and Medical Genetics, Medical Faculty, Trakia University, Stara Zagora 6000, Bulgaria., Velikova T; Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of virology [World J Virol] 2021 Jul 25; Vol. 10 (4), pp. 137-155. |
| DOI: | 10.5501/wjv.v10.i4.137 |
| Abstrakt: | Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe coronavirus disease 2019 (COVID-19). Hence, it seems that genetics matters here, as well. Nevertheless, the virus's nature, including its RNA structure, determines the rate of mutations leading to new viral strains with all epidemiological and clinical consequences. Given these observations, we herein comment on the current hypotheses about the possible role of the genes in association with COVID-19 severity. We discuss some of the major candidate genes that have been identified as potential genetic factors associated with the COVID-19 severity and infection susceptibility: HLA, ABO, ACE2, TLR7, ApoE, TYK2, OAS, DPP9, IFNAR2, CCR2 , etc. Further study of genes and genetic variants will be of great benefit for the prevention and assessment of the individual risk and disease severity in different populations. These scientific data will serve as a basis for the development of clinically applicable diagnostic and prognostic tests for patients at high risk of COVID-19. Competing Interests: Conflict-of-interest statement: Authors declare no conflict of interests for this article. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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