Characteristics of Serrated Adenomas in Non-Hispanic Whites and African Americans Undergoing Screening Colonoscopy.

Autor:	Stemboroski L; Gastroenterology, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Samuel J; Internal Medicine, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Alkaddour A; Gastroenterology and Hepatology, Augusta University Medical College of Georgia, Augusta, USA., Agresti N; Gastroenterology, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Gupta E; Internal Medicine, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Palacio C; Internal Medicine, University of Florida, Jacksonville, USA., Munoz JC; Gastroenterology, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Deutch A; Gastroenterology, University of Florida - Jacksonville College of Medicine (COM), Jacksonville, USA., Yap JEL; Gastroenterology and Hepatology, Augusta University Medical College of Georgia, Augusta, USA., Vega KJ; Gastroenterology and Hepatology, Augusta University Medical College of Georgia, Augusta, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Jul 05; Vol. 13 (7), pp. e16200. Date of Electronic Publication: 2021 Jul 05 (Print Publication: 2021).
DOI:	10.7759/cureus.16200
Abstrakt:	Background and aim Adenomatous polyps are precursor lesions for colorectal cancer (CRC). Serrated adenomas/polyps are considered a risk factor for the development of proximal and interval CRC. African-Americans are at higher risk for right-sided CRC. Minimal data evaluating serrated adenoma characteristics by race/ethnicity on initial screening colonoscopy (SC) exist. The aim of this investigation was to compare the characteristics of serrated adenomas found in non-Hispanic whites (nHw) and African-Americans (AA) undergoing initial SC. Methods The University of Florida-Jacksonville endoscopy database was searched for all SC performed between January 2000 and December 2014. Inclusion criteria were nHw or AA race/ethnicity and histologically proven serrated adenoma found at SC. Data were collected for all included age at SC, sex, number, location, and size of serrated adenomas found. Results A total of 8693 individuals (nHw - 4199 and AA - 4494) underwent SC between January 2000 and December 2014. Serrated adenomas were found in 479 individuals (nHw, n=294; AA, n=185), and AA were significantly less likely than nHw to have serrated adenomas on SC (AA 4.1% vs nHw 7%; p< 0.0001). No difference was observed in mean age, location, or size between nHw and AA with serrated adenomas. Conclusions Serrated adenomas are more frequent in nHw compared to AA at initial SC. No difference was seen in size or location of serrated adenomas, as well as patient age, between AA and nHw. A study of genetic factors predisposing to serrated adenoma formation and the impact of socioeconomic disparities should be performed across ethnic groups to understand this difference. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Stemboroski et al.)
Databáze:	MEDLINE
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