Parvovirus Infection and Thrombotic Thrombocytopenic Purpura in an Adult Patient With Sickle Cell Beta-Thalassemia.
| Autor: | Shaik L; Cardiovascular Diseases, Mayo Clinic, Rochester, USA., Ranjha S; Internal Medicine, Ahktar Saeed Medical College, Lahore, PAK., Katta RR; internal Medicine, Mayo Clinic, Rochester, USA., Shah R; Internal Medicine, M. P. Shah Government Medical College, Jamnagar, IND., Nelekar S; Internal Medicine, Dr. Vaishampayan Memorial Govt Medical College, Solapur, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Jul 04; Vol. 13 (7), pp. e16173. Date of Electronic Publication: 2021 Jul 04 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.16173 |
| Abstrakt: | Parvovirus infection and thrombotic thrombocytopenic purpura (TTP) are rare manifestations in adults with sickle cell beta-thalassemia. Due to the lack of a clear demarcation between the complications related to sickle cell disease (SCD) and TTP, the diagnosis is often challenging. The treatment requirements for both these entities are divergent and complicated, thus necessitating a careful plan of action during atypical presentations. Here we present a case of a 22-year-old woman during the peripartum period with fever, generalized body aches, and large joint pains that soon evolved into labor. The patient's history was suggestive of an undiagnosed and inherited blood disorder. The presentation of aplastic crisis-splenic sequestration during early adulthood is atypical for the SCD course in general populations. Moreover, as the patient's clinical status deteriorated with blood transfusion, the diagnosis and management of a sickle cell crisis event and TTP added to the dilemma in the presence of non-classic parvovirus infection. Though the causation of TTP due to SCD-parvovirus infection is questionable, the treatment of the baseline sickle cell crisis with the novel supportive measures resolved the underlying complications in our patient, suggesting the causal effect. As a result of this, we emphasize the importance of being vigilant about such atypical presentations to avoid delays in diagnosis and treatment of such life-threatening emergencies like TTP. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Shaik et al.) |
| Databáze: | MEDLINE |
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