Aggregation-Enhanced Photoluminescence and Photoacoustics of Atomically Precise Gold Nanoclusters in Lipid Nanodiscs (NANO 2 ).

Autor: Rad AT; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA., Bao Y; Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA., Jang HS; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA; Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea., Xia Y; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA., Sharma H; Department of Physics, University of Connecticut, Storrs, CT 06269, USA., Dormidontova EE; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA; Department of Physics, University of Connecticut, Storrs, CT 06269, USA., Zhao J; Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA., Arora J; Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, USA., John VT; Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, LA 70118, USA., Tang BZ; Department of Chemistry, the Hong Kong University of Science and Technology, Hong Kong, P. R. China., Dainese T; Department of Chemistry, University of Padova, Padova 35131, Italy., Hariri A; Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA., Jokerst JV; Department of NanoEngineering, University of California San Diego, La Jolla, CA 92093, USA., Maran F; Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA, Department of Chemistry, University of Padova, Padova 35131, Italy., Nieh MP; Department of Biomedical Engineering, University of Connecticut Storrs, CT 06269, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA; Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, USA.
Jazyk: angličtina
Zdroj: Advanced functional materials [Adv Funct Mater] 2021 Mar 03; Vol. 31 (10). Date of Electronic Publication: 2020 Dec 13.
DOI: 10.1002/adfm.202009750
Abstrakt: The authors designed a structurally stable nano-in-nano (NANO 2 ) system highly capable of bioimaging via an aggregation-enhanced NIR excited emission and photoacoustic response achieved based on atomically precise gold nanoclusters protected by linear thiolated ligands [Au 25 (SC n H 2 n +1 ) 18 , n = 4-16] encapsulated in discoidal phospholipid bicelles through a one-pot synthesis. The detailed morphological characterization of NANO 2 is conducted using cryogenic transmission electron microscopy, small/wide angle X-ray scattering with the support of molecular dynamics simulations, providing information on the location of Au nanoclusters in NANO 2 . The photoluminescence observed for NANO 2 is 20-60 times more intense than that of the free Au nanoclusters, with both excitation and emission wavelengths in the near-infrared range, and the photoacoustic signal is more than tripled. The authors attribute this newly discovered aggregation-enhanced photoluminescence and photoacoustic signals to the restriction of intramolecular motion of the clusters' ligands. With the advantages of biocompatibility and high cellular uptake, NANO 2 is potentially applicable for both in vitro and in vivo imaging, as the authors demonstrate with NIR excited emission from in vitro A549 human lung and the KB human cervical cancer cells.
Competing Interests: Conflict of Interest The authors declare no conflict of interest.
Databáze: MEDLINE
Externí odkaz: