Head-to-head comparison between 68Ga-PSMA and 18F-FDG-PET/CT in lymphomas: a preliminary analysis.

Autor:	de Souza SPM; Division of Nuclear Medicine, Department of Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP)., Tobar N; Division of Nuclear Medicine, Department of Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP)., Frasson F; Division of Nuclear Medicine, Department of Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP)., Perini EA; Nuclear and Energy Research Institute (IPEN)., de Souza CA; Division of Hematology, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil., Delamain MT; Division of Hematology, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas (UNICAMP), São Paulo, Brazil., Ramos CD; Division of Nuclear Medicine, Department of Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP).
Jazyk:	angličtina
Zdroj:	Nuclear medicine communications [Nucl Med Commun] 2021 Dec 01; Vol. 42 (12), pp. 1355-1360.
DOI:	10.1097/MNM.0000000000001465
Abstrakt:	Purpose: Isolated case reports mention the uptake of radiolabeled PSMA in lymphoma. However, it is not clear if the intensity of 68Ga-PSMA expression varies among different histological subtypes or if it correlates with 18F-FDG uptake. This study compared both tracers in patients with diverse lymphoma subtypes. Methods: Ten patients with biopsy-proven-lymphoma underwent 18F-FDG and 68Ga-PSMA-PET/CT (maximum time interval: 6 days). Lymphoma subtypes included Hodgkin's lymphoma (HL, three patients) and aggressive and indolent non-Hodgkin's lymphoma (NHL, seven patients). The intensity of PSMA uptake was classified visually as low, intermediate, or high, using blood pool, liver and parotid gland uptake as references. Maximum standardized-uptake value (SUVmax) of each affected site was measured in both sets of images. Results: FDG detected 59/59 involved sites in 10 patients and PSMA 47/59 sites in nine patients. PSMA uptake was generally low, regardless of the intensity of FDG uptake, but it was classified as intermediate in two patients. The median SUVmax varied from 2.0 (2.0-8.2) to 30.9 for FDG and from 1.7 (1.7-1.7) to 4.4 for PSMA, P < 0.0001. The primary lesion of one patient had a marked intralesional mismatch uptake pattern of the tracers, with areas of higher PSMA expression than FDG uptake, and vice-versa. A brain lesion was more easily identified with PSMA than with FDG images. Conclusion: HL and several NHL subtypes may present PSMA uptake. The intensity of PSMA expression is generally lower than that of FDG uptake and seems to present less variation among the different histological subtypes of lymphomas. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu