The Role of Stem Cells in the Therapy of Stroke.

Autor:	Ejma M; Department of Neurology, Wroclaw Medical University, 50-556 Wrocław, Borowska 213, Poland., Madetko N; Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warszawa, Poland., Brzecka A; Department of Pulmonology and Lung Oncology, Wroclaw Medical University, Grabiszynska 105, 53-439 Wroclaw, Poland., Alster P; Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warszawa, Poland., Budrewicz S; Department of Neurology, Wroclaw Medical University, 50-556 Wrocław, Borowska 213, Poland., Koszewicz M; Department of Neurology, Wroclaw Medical University, 50-556 Wrocław, Borowska 213, Poland., Misiuk-Hojło M; Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, Borowska 213, Poland., Tomilova IK; Department of Biochemistry, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, 153012, Russian Federation., Somasundaram SG; Department of Biological Sciences, Salem University, Salem, WV, 26426, USA., Kirkland CE; Department of Biological Sciences, Salem University, Salem, WV, 26426, USA.
Jazyk:	angličtina
Zdroj:	Current neuropharmacology [Curr Neuropharmacol] 2022 Mar 04; Vol. 20 (3), pp. 630-647.
DOI:	10.2174/1570159X19666210806163352
Abstrakt:	Background: Stroke is a major challenge in neurology due to its multifactorial genesis and irreversible consequences. Processes of endogenous post-stroke neurogenesis, although insufficient, may indicate possible direction of future therapy. Multiple research considers stem-cell-based approaches in order to maximize neuroregeneration and minimize post-stroke deficits. Objective: Aim of this study is to review current literature considering post-stroke stem-cell- based therapy and possibilities of inducing neuroregeneration after brain vascular damage. Methods: Papers included in this article were obtained from PubMed and MEDLINE databases. The following medical subject headings (MeSH) were used: "stem cell therapy", "post-stroke neurogenesis", "stem-cells stroke", "stroke neurogenesis", "stroke stem cells", "stroke", "cell therapy", "neuroregeneration", "neurogenesis", "stem-cell human", "cell therapy in human". Ultimate inclusion was made after manual review of the obtained reference list. Results: Attempts of stimulating neuroregeneration after stroke found in current literature include supporting endogenous neurogenesis, different routes of exogenous stem cells supplying and extracellular vesicles used as a method of particle transport. Conclusion: Although further research in this field is required, post stroke brain recovery supported by exogenous stem cells seems to be promising future therapy revolutionizing modern neurology. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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