Metastatic Breast Cancer, Organotropism and Therapeutics: A Review.
| Autor: | Waza AA; Multidisciplinary Research Unit (MRU), Government Medical College (GMC) Srinagar, J & K, 190010, India; 2Centre of Research for Development, University of Kashmir, Srinagar 190006, India., Tarfeen N; Centre of Research for Development, University of Kashmir, Srinagar 190006, India., Majid S; Department of Biochemistry, Government Medical College (GMC) Srinagar, J & K, 190010, India., Hassan Y; Division of Nursing, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, J & K, India., Mir R; Department of Medical Lab Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., Rather MY; Multidisciplinary Research Unit (MRU), Government Medical College (GMC) Srinagar, J & K, 190010, India; 2Centre of Research for Development, University of Kashmir, Srinagar 190006, India., Shah NUD; Centre of Research for Development, University of Kashmir, Srinagar 190006, India. |
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| Jazyk: | angličtina |
| Zdroj: | Current cancer drug targets [Curr Cancer Drug Targets] 2021; Vol. 21 (10), pp. 813-828. |
| DOI: | 10.2174/1568009621666210806094410 |
| Abstrakt: | The final stage of breast cancer involves spreading breast cancer cells to the vital organs like the brain, liver lungs and bones in the process called metastasis. Once the target organ is overtaken by the metastatic breast cancer cells, its usual function is compromised causing organ dysfunction and death. Despite the significant research on breast cancer metastasis, it's still the main culprit of breast cancer-related deaths. Exploring the complex molecular pathways associated with the initiation and progression of breast cancer metastasis could lead to the discovery of more effective ways of treating the devastating phenomenon. The present review article highlights the recent advances to understand the complexity associated with breast cancer metastases, organotropism and therapeutic advances. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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