Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers.

Autor: Mohamady Hussein MA; Clinic of Dermatology, University Hospital of RWTH Aachen, Aachen 52074, Germany; Department of Pharmacology, Medical Research Division, National Research Center, Dokki, Cairo 12622, Egypt. Electronic address: almohammadeymr2023@gmail.com., Guler E; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, Turkey; Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey., Rayaman E; Department of Pharmaceutical Microbiology, Marmara University, Istanbul, Turkey. Electronic address: erayaman@marmara.edu., Cam ME; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, Turkey; Department of Pharmacology, Faculty of Pharmacy, Marmara University, Istanbul 34716, Turkey; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. Electronic address: m.cam@ucl.ac.uk., Sahin A; Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, 34722 Istanbul, Turkey. Electronic address: alisahin@marmara.edu.tr., Grinholc M; Laboratory of Molecular Diagnostics, Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk, Gdansk, Poland. Electronic address: mariusz.grinholc@biotech.ug.edu.pl., Sezgin Mansuroglu D; Polymer Technologies and Composite Application and Research Center (ArelPOTKAM), Istanbul Arel University, Istanbul 34537, Turkey., Sahin YM; Polymer Technologies and Composite Application and Research Center (ArelPOTKAM), Istanbul Arel University, Istanbul 34537, Turkey. Electronic address: ymugesahin@arel.edu.tr., Gunduz O; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, Turkey. Electronic address: oguzhan@marmara.edu.tr., Muhammed M; KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden. Electronic address: mamoun@kth.se., El-Sherbiny IM; Nanomedicine Laboratory, Center for Materials Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12578, Egypt. Electronic address: ielsherbiny@zewailcity.edu.eg., Megahed M; Clinic of Dermatology, University Hospital of RWTH Aachen, Aachen 52074, Germany. Electronic address: mmegahed@ukaachen.de.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2021 Oct 15; Vol. 270, pp. 118373. Date of Electronic Publication: 2021 Jun 26.
DOI: 10.1016/j.carbpol.2021.118373
Abstrakt: Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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