Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values.

Autor: de Oliveira Paludo FJ; Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil., de Bittencourt Pasquali MA; Programa de Pós-Graduação de Engenharia e Gestão de Recursos Naturais, Centro de Tecnologia de Recursos Naturais, Universidade Federal Campina Grande, Av. Aprígio Veloso 882, 58429-200 Campina Grande, Paraíba, Brazil. Electronic address: matheus.augusto@professor.ufcg.edu.br., de Vargas AR; Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil., de Oliveira IB; Programa de Pós-Graduação de Engenharia e Gestão de Recursos Naturais, Centro de Tecnologia de Recursos Naturais, Universidade Federal Campina Grande, Av. Aprígio Veloso 882, 58429-200 Campina Grande, Paraíba, Brazil., Gonçalves LVB; Programa de Pós-Graduação de Engenharia e Gestão de Recursos Naturais, Centro de Tecnologia de Recursos Naturais, Universidade Federal Campina Grande, Av. Aprígio Veloso 882, 58429-200 Campina Grande, Paraíba, Brazil., Gelain DP; Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil., Moreira JCF; Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035-003 Porto Alegre, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Oct; Vol. 142, pp. 111993. Date of Electronic Publication: 2021 Aug 05.
DOI: 10.1016/j.biopha.2021.111993
Abstrakt: Superoxide dismutase 2 (SOD2) is an antioxidant enzyme that appears phylogenetically conserved. However, functional Sod2 polymorphisms have been studied, and the specific polymorphisms are related to activity alterations of the SOD2 enzyme. An example of a polymorphism of SOD2 is Val16Ala (rs4880), which has been identified in exon 2 of the human Sod2 gene. This polymorphism is recognized as a single nucleotide polymorphism (SNP) and alters the conformation of SOD2. Additionally, recent studies have shown that the Ala16 Val polymorphism in Sod2 can be related to different pathological diseases. In these terms, the objective of the present study was to evaluate whether the polymorphism of SOD2 in Val16Ala (rs4880) influences the motility and vigor of X- and Y-bearing sperm at different pH values promoting sperm selection. We found that polymorphism rs4880 at normal pH conditions can result in alterations in the activity of superoxide dismutase in the sperm through different assay analyses. Moreover, compelling modulation evidence indicates that this effect could also mediate seminal plasma redox alterations and consequently can play an important role in sperm physiology, fertilization, and postfertilization.
(Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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