Timing the evolution of antioxidant enzymes in cyanobacteria.

Autor: Boden JS; School of Geographical Sciences, University of Bristol, Bristol, United Kingdom., Konhauser KO; Department of Earth and Atmospheric Sciences, University of Alberta, Edmonton, AB, Canada., Robbins LJ; Department of Earth and Planetary Sciences, Yale University, New Haven, CT, USA.; Department of Geology, University of Regina, Regina, SK, Canada., Sánchez-Baracaldo P; School of Geographical Sciences, University of Bristol, Bristol, United Kingdom. p.sanchez-baracaldo@bristol.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Aug 06; Vol. 12 (1), pp. 4742. Date of Electronic Publication: 2021 Aug 06.
DOI: 10.1038/s41467-021-24396-y
Abstrakt: The ancestors of cyanobacteria generated Earth's first biogenic molecular oxygen, but how they dealt with oxidative stress remains unconstrained. Here we investigate when superoxide dismutase enzymes (SODs) capable of removing superoxide free radicals evolved and estimate when Cyanobacteria originated. Our Bayesian molecular clocks, calibrated with microfossils, predict that stem Cyanobacteria arose 3300-3600 million years ago. Shortly afterwards, we find phylogenetic evidence that ancestral cyanobacteria used SODs with copper and zinc cofactors (CuZnSOD) during the Archaean. By the Paleoproterozoic, they became genetically capable of using iron, nickel, and manganese as cofactors (FeSOD, NiSOD, and MnSOD respectively). The evolution of NiSOD is particularly intriguing because it corresponds with cyanobacteria's invasion of the open ocean. Our analyses of metalloenzymes dealing with reactive oxygen species (ROS) now demonstrate that marine geochemical records alone may not predict patterns of metal usage by phototrophs from freshwater and terrestrial habitats.
(© 2021. Crown.)
Databáze: MEDLINE
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