Increased Pericardial Adipose Tissue in Smokers.

Autor: Zimmermann GS; Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany., Ruether T; Department of Psychiatry, Ludwig-Maximilians-University Munich, 80336 Munich, Germany., von Ziegler F; Department of Cardiology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Greif M; Department of Cardiology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany., Tittus J; Department of Cardiology, Klinikum Augustinum Munich, 81375 Munich, Germany., Schenzle J; Department of Cardiology, Klinikum Garmisch-Partenkirchen, 82467 Garmisch-Partenkirchen, Germany., Becker C; Department of Clinical Radiology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.; Cardiovascular Imaging Division, Department of Radiology, Stanford University Medical Center, Stanford, CA 94305, USA., Becker A; Department of Cardiology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Jul 30; Vol. 10 (15). Date of Electronic Publication: 2021 Jul 30.
DOI: 10.3390/jcm10153382
Abstrakt: Background: Pericardial adipose tissue (PAT), a visceral fat depot directly located to the heart, is associated with atherosclerotic and inflammatory processes. The extent of PAT is related to the prevalence of coronary heart disease and might be used for cardiovascular risk prediction. This study aimed to determine the effect of smoking on the extent of PAT.
Methods: We retrospectively examined 1217 asymptomatic patients (490 females, age 58.3 ± 8.3 years, smoker n = 573, non-smoker n = 644) with a multislice CT scanner and determined the PAT volume. Coronary risk factors were determined at inclusion, and a multivariate analysis was performed to evaluate the influence of smoking on PAT independent from accompanying risk factors.
Results: The mean PAT volume was 215 ± 107 mL in all patients. The PAT volume in smokers was significantly higher compared to PAT volume in non-smokers (231 ± 104 mL vs. 201 ± 99 mL, p = 0.03). Patients without cardiovascular risk factors showed a significantly lower PAT volume (153 ± 155 mL, p < 0.05) compared to patients with more than 1 risk factor. Odds ratio was 2.92 [2.31, 3.61; p < 0.001] for elevated PAT in smokers.
Conclusion: PAT as an individual marker of atherosclerotic activity and inflammatory burden was elevated in smokers. The finding was independent from metabolic risk factors and might therefore illustrate the increased inflammatory activity in smokers in comparison to non-smokers.
Databáze: MEDLINE
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