| Autor: |
Pereira PS; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Oliveira CVB; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Maia AJ; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Tintino SR; Centro para el Desarrollo de la Investigación Científica (CEDIC), Fundación Moisés Bertoni/Laboratorios Díaz Gill., Asunción 1255, Paraguay., Oliveira-Tintino CDM; Centro para el Desarrollo de la Investigación Científica (CEDIC), Fundación Moisés Bertoni/Laboratorios Díaz Gill., Asunción 1255, Paraguay., Vega-Gomez MC; Centro para el Desarrollo de la Investigación Científica (CEDIC), Fundación Moisés Bertoni/Laboratorios Díaz Gill., Asunción 1255, Paraguay., Rolón M; Centro para el Desarrollo de la Investigación Científica (CEDIC), Fundación Moisés Bertoni/Laboratorios Díaz Gill., Asunción 1255, Paraguay., Coronel C; Centro para el Desarrollo de la Investigación Científica (CEDIC), Fundación Moisés Bertoni/Laboratorios Díaz Gill., Asunción 1255, Paraguay., Duarte AE; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Barros LM; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Kamdem JP; Laboratório de Farmacologia e Química Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil., Siyadatpanah A; Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran., Wilairatana P; Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand., Coutinho HDM; Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Rua Cel. Antonio Luis 1161, Pimenta, Crato 63105-000, Brazil. |
| Abstrakt: |
The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea . The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC 50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research. |
