Plasmodium falciparum: responses of a semi-immune individual to homologous and heterologous challenges, and non-infectivity of gametocytes in Anopheles stephensi.

Autor: McCarthy VC, Clyde DF, Woodward WE
Jazyk: angličtina
Zdroj: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1978 Jan; Vol. 27 (1 Pt 1), pp. 6-8.
DOI: 10.4269/ajtmh.1978.27.6
Abstrakt: With strict adherence to ethical guidelines, a semi-immune volunteer was exposed to homologous and heterologous blood challenges with strains of Plasmodium falciparum from Vietnam and Tanzania. On both occasions infections developed, but clinical manifestations were moderated, prepatent periods increased, and parasitemias limited. Gametocytes produced by these infections failed to infect Anopheles stephensi. Possible reasons for this are discussed.
Databáze: MEDLINE