| Autor: |
Eng JM; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada.; Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada., Estall JL; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada.; Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada. |
| Jazyk: |
angličtina |
| Zdroj: |
Cells [Cells] 2021 Jul 16; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 16. |
| DOI: |
10.3390/cells10071805 |
| Abstrakt: |
Non-alcoholic fatty liver disease (NAFLD) affects approximately 1 in 4 people worldwide and is a major burden to health care systems. A major concern in NAFLD research is lack of confidence in pre-clinical animal models, raising questions regarding translation to humans. Recently, there has been renewed interest in creating dietary models of NAFLD with higher similarity to human diets in hopes to better recapitulate disease pathology. This review summarizes recent research comparing individual roles of major dietary components to NAFLD and addresses common misconceptions surrounding frequently used diet-based NAFLD models. We discuss the effects of glucose, fructose, and sucrose on the liver, and how solid vs. liquid sugar differ in promoting disease. We consider studies on dosages of fat and cholesterol needed to promote NAFLD versus NASH, and discuss important considerations when choosing control diets, mouse strains, and diet duration. Lastly, we provide our recommendations on amount and type of sugar, fat, and cholesterol to include when modelling diet-induced NAFLD/NASH in mice. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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