| Autor: |
Scoffone VC; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Trespidi G; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Barbieri G; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Irudal S; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Perrin E; Department of Biology, University of Florence, 50019 Sesto Fiorentino, Italy., Buroni S; Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy. |
| Abstrakt: |
Drug resistance represents a great concern among people with cystic fibrosis (CF), due to the recurrent and prolonged antibiotic therapy they should often undergo. Among Multi Drug Resistance (MDR) determinants, Resistance-Nodulation-cell Division (RND) efflux pumps have been reported as the main contributors, due to their ability to extrude a wide variety of molecules out of the bacterial cell. In this review, we summarize the principal RND efflux pump families described in CF pathogens, focusing on the main Gram-negative bacterial species ( Pseudomonas aeruginosa , Burkholderia cenocepacia , Achromobacter xylosoxidans , Stenotrophomonas maltophilia ) for which a predominant role of RND pumps has been associated to MDR phenotypes. |
