A microelectronic conductimetric biosensor.

Autor: Watson LD; Biotechnology Centre, University of Cambridge, Great Britain., Maynard P, Cullen DC, Sethi RS, Brettle J, Lowe CR
Jazyk: angličtina
Zdroj: Biosensors [Biosensors] 1987-1988; Vol. 3 (2), pp. 101-15.
DOI: 10.1016/s0265-928x(87)80003-2
Abstrakt: The fabrication and operation of a microelectronic conductimetric biosensor is described. The device monitors the change in solution conductance occasioned by the catalytic action of enzymes immobilised over a planar conductance cell comprising serpentined and interdigitated metal conductor tracks. The output of the instrument was linear over a 3 min period on addition of urea to a sample cell overlaid with immobilised urease. The responses to any given urea concentration were reproducible to within approximately +/- 1%. The device responds to urea present in serum samples.
Databáze: MEDLINE