Preoperative imaging of glioblastoma patients using hyperpolarized 13 C pyruvate: Potential role in clinical decision making.

Autor:	Chen J; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Patel TR; Department of Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Pinho MC; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Choi C; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Harrison CE; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Baxter JD; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Derner K; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Pena S; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Liticker J; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Raza J; Department of Pharmacy Practice, Texas Tech University Health Sciences Center, Dallas, Texas, USA., Hall RG; Department of Pharmacy Practice, Texas Tech University Health Sciences Center, Dallas, Texas, USA., Reed GD; GE Healthcare, Dallas, Texas, USA., Cai C; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Hatanpaa KJ; Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bankson JA; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Bachoo RM; Department of Neurosurgery and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Malloy CR; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Mickey BE; Department of Neurosurgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA., Park JM; Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Department of Electrical and Computer Engineering, The University of Texas at Dallas, Richardson, Texas, USA.
Jazyk:	angličtina
Zdroj:	Neuro-oncology advances [Neurooncol Adv] 2021 Jun 28; Vol. 3 (1), pp. vdab092. Date of Electronic Publication: 2021 Jun 28 (Print Publication: 2021).
DOI:	10.1093/noajnl/vdab092
Abstrakt:	Background: Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells. 13 C MR spectroscopic imaging with hyperpolarized pyruvate can demonstrate alterations in pyruvate metabolism in these tumors. Methods: Three patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3 T 1-2 days prior to tumor resection using a 13 C/ 1 H dual-frequency RF coil and a 13 C/ 1 H-integrated MR protocol, which consists of a series of 1 H MR sequences (T 2 FLAIR, arterial spin labeling and contrast-enhanced [CE] T 1 ) and 13 C spectroscopic imaging with hyperpolarized [1- 13 C]pyruvate. Dynamic spiral chemical shift imaging was used for 13 C data acquisition. Surgical navigation was used to correlate the locations of tissue samples submitted for histology with the changes seen on the diagnostic MR scans and the 13 C spectroscopic images. Results: Each tumor was histologically confirmed to be a WHO grade IV glioblastoma with isocitrate dehydrogenase wild type. Total hyperpolarized 13 C signals detected near the tumor mass reflected altered tissue perfusion near the tumor. For each tumor, a hyperintense [1- 13 C]lactate signal was detected both within CE and T 2 -FLAIR regions on the 1 H diagnostic images ( P = .008). [ 13 C]bicarbonate signal was maintained or decreased in the lesion but the observation was not significant ( P = .3). Conclusions: Prior to surgical resection, 13 C MR spectroscopic imaging with hyperpolarized pyruvate reveals increased lactate production in regions of histologically confirmed glioblastoma. (© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)
Databáze:	MEDLINE
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