Photostability enhancement of silica-coated gold nanostars for photoacoustic imaging guided photothermal therapy.
| Autor: | Chen Y; Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China., Xu C; The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, PR China., Cheng Y; The Institute for Translational Nanomedicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai, PR China., Cheng Q; Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, PR China.; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China. |
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| Jazyk: | angličtina |
| Zdroj: | Photoacoustics [Photoacoustics] 2021 Jul 17; Vol. 23, pp. 100284. Date of Electronic Publication: 2021 Jul 17 (Print Publication: 2021). |
| DOI: | 10.1016/j.pacs.2021.100284 |
| Abstrakt: | Gold nanostars (GNSs) are promising contrast agents for simultaneous photothermal therapy and photoacoustic imaging (PAI) owing to their excellent photothermal conversion efficiency. However, GNSs are easily reshaped under transient high-intensity laser pulses, which can cause a rapid shift in the light absorption peak, resulting in a decrease in both therapeutic and monitoring effects. In this work, we synthesized GNSs without toxic surfactants and coated them with a silica shell to retain their shape, thus maintaining their photostability. The excellent performance of these silica-coated GNSs was verified through both in vitro and in vivo PAI experiments. The silica-coated GNSs exhibited a threefold improvement in photoacoustic stability, as compared with the non-coated GNSs. The proposed silica coating method for GNSs was found to improve the photostability of GNSs, making them efficient, safe, and reliable nanoparticles for PAI. Competing Interests: The authors report no declarations of interest. (© 2021 The Authors.) |
| Databáze: | MEDLINE |
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