The role of β-hairpin conformation in ester hydrolysis peptide catalysts based on a TrpZip scaffold.
| Autor: | Liu X; Department of Chemistry, University of Wisconsin-Madison Madison Wisconsin 53706 USA., Waters R; Department of Chemistry, Macalester College Saint Paul Minnesota 55105 USA lwitus@macalester.edu., Gilbert HE; Department of Chemistry, Macalester College Saint Paul Minnesota 55105 USA lwitus@macalester.edu., Barroso GT; Department of Chemistry, Macalester College Saint Paul Minnesota 55105 USA lwitus@macalester.edu., Boyle KM; Department of Chemistry, Macalester College Saint Paul Minnesota 55105 USA lwitus@macalester.edu., Witus LS; Department of Chemistry, Macalester College Saint Paul Minnesota 55105 USA lwitus@macalester.edu. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2021 Jul 06; Vol. 11 (38), pp. 23714-23718. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021). |
| DOI: | 10.1039/d1ra04288b |
| Abstrakt: | To explore the role of peptide conformation on catalytic activity in the context of ester hydrolysis catalysts, pairs of sequences were designed that contained or lacked β-hairpin character. For the hydrolysis of para -nitrophenylacetate in aqueous media, we found small but consistent trends wherein His-containing sequences based on a TrpZip scaffold showed higher catalytic activity without β-hairpin character. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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