Measure Partial Liver Volumetric Variations from Paired Inspiratory-expiratory Chest CT Scans.

Autor:	Luo C; Data Science Institute, Vanderbilt University, Nashville, TN, 37235 USA., Terry JG; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235 USA., Tang Y; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235 USA., Xu K; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235 USA., Massion PP; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN, USA 37235., Landman BA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235 USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 37235 USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235 USA.; Institute of Imaging Science, Vanderbilt University, Nashville, TN, 37235 USA., Carr JJ; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, 37235 USA.; Department of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, 37235 USA.; Institute of Imaging Science, Vanderbilt University, Nashville, TN, 37235 USA.; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235 USA., Huo Y; Data Science Institute, Vanderbilt University, Nashville, TN, 37235 USA.; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235 USA.
Jazyk:	angličtina
Zdroj:	Proceedings of SPIE--the International Society for Optical Engineering [Proc SPIE Int Soc Opt Eng] 2021; Vol. 11596. Date of Electronic Publication: 2021 Feb 15.
DOI:	10.1117/12.2581077
Abstrakt:	Liver stiffness is an essential clinical biomarker for diagnosing liver fibrosis and cirrhosis. In current clinical practice, elastography techniques are standard non-invasive diagnosis tools to assess stiffness of liver, using either Ultrasound (US) or magnetic resonance imaging (MRI). However, the US elastography yields ≈ 10 % failure rate and degraded performance on obese patients, while the MR elastography is costlier and less available. Compared with US and MRI, the computerized tomography (CT) imaging has not been widely used in measuring liver stiffness. In this paper, we performed a pilot study to assess if volumetric variations of liver can be captured from paired inspiratory-expiratory chest (PIEC) CT scans. To enable the assessment, we propose a Hierarchical Intra-Patient Organ-specific (HIPO) registration pipeline to quantify the partial liver volumetric variations with lung pressure from a respiratory cycle. The PIEC protocol is employed since it naturally provides two paired CT scans with liver deformation from regulated respiratory motions. For the subjects whose registration results passed both an automatic quantitative quality assurance (QA) and another visual qualitative QA, 6.0% average volumetric variations of liver were measured, from inspiratory phase to expiratory phase. Future clinical validations will be required to validate the findings in this pilot study.
Databáze:	MEDLINE
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