Transposable elements shape the evolution of mammalian development.

Autor: Senft AD; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD, USA. anna.senft@nih.gov., Macfarlan TS; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD, USA. todd.macfarlan@nih.gov.
Jazyk: angličtina
Zdroj: Nature reviews. Genetics [Nat Rev Genet] 2021 Nov; Vol. 22 (11), pp. 691-711. Date of Electronic Publication: 2021 Aug 05.
DOI: 10.1038/s41576-021-00385-1
Abstrakt: Transposable elements (TEs) promote genetic innovation but also threaten genome stability. Despite multiple layers of host defence, TEs actively shape mammalian-specific developmental processes, particularly during pre-implantation and extra-embryonic development and at the maternal-fetal interface. Here, we review how TEs influence mammalian genomes both directly by providing the raw material for genetic change and indirectly via co-evolving TE-binding Krüppel-associated box zinc finger proteins (KRAB-ZFPs). Throughout mammalian evolution, individual activities of ancient TEs were co-opted to enable invasive placentation that characterizes live-born mammals. By contrast, the widespread activity of evolutionarily young TEs may reflect an ongoing co-evolution that continues to impact mammalian development.
(© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.)
Databáze: MEDLINE
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