| Autor: |
Benvegnú E; Postgraduate Program on Bioexperimentation, University of Passo Fundo (UPF), Campus I, BR 285, Bairro São José, Passo Fundo, Rio Grande do Sul99052-900, Brazil., Hermes CC; Postgraduate Program on Bioexperimentation, University of Passo Fundo (UPF), Campus I, BR 285, Bairro São José, Passo Fundo, Rio Grande do Sul99052-900, Brazil., Guizzo JA; Postgraduate Program on Veterinary Medicine, Federal University of Santa Maria, Santa Maria97105-900, Brazil., Soares SM; Postgraduate Program on Pharmacology, Federal University of Santa Maria, Santa Maria97105-900, Brazil., Costa MM; Postgraduate Program on Bioexperimentation, University of Passo Fundo (UPF), Campus I, BR 285, Bairro São José, Passo Fundo, Rio Grande do Sul99052-900, Brazil., Rodriguez R; Pathology Institute of Passo Fundo, Rua Teixeira Soares 885, Centro, 99010-08Passo Fundo, Brazil., Frandoloso R; Postgraduate Program on Bioexperimentation, University of Passo Fundo (UPF), Campus I, BR 285, Bairro São José, Passo Fundo, Rio Grande do Sul99052-900, Brazil., Vieira MIB; Postgraduate Program on Bioexperimentation, University of Passo Fundo (UPF), Campus I, BR 285, Bairro São José, Passo Fundo, Rio Grande do Sul99052-900, Brazil. |
| Abstrakt: |
This study describes changes in haematological parameters, cytokine profile, histopathology and cortisol levels in Swiss mice experimentally infected with Angiostrongylus costaricensis. Twenty-eight Swiss mice were divided into two groups (G1 and G2) of 14 animals each. In each group, eight animals were infected orally with ten third-stage larvae of A. costaricensis and six were used as a control group. The mice of groups G1 and G2 were sacrificed 14 and 24 days after infection, respectively. Samples were collected for histopathological and haematological analyses and determination of the cytokine profile and cortisol levels. Granulomatous reaction, eosinophilic infiltrate and vasculitis in the intestinal tract, pancreas, liver and spleen were observed with varying intensity in infected animals. Our results showed that the mice developed normocytic and hypochromic anaemia, and that the histopathological lesions caused by the experimental infection influenced increases in cortisol, neutrophil and monocyte levels. In addition to this, we detected increased interleukin-6 and tumour necrosis factor alpha levels in the infected animals. |
